Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles

Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles

Paclitaxel (PTX, taxol), a classical antitumor drug against a wide range of tumors, shows poor oral bioavailability. In order to improve the oral bioavailability of PTX, glycyrrhizic acid (GA) was used as the carrier in this study. This was the first report on the preparation, characterization and t...

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Bibliographic Details
Main Authors: Fu-Heng Yang, Qing Zhang, Qian-Ying Liang, Sheng-Qi Wang, Bo-Xin Zhao, Ya-Tian Wang, Yun Cai, Guo-Feng Li
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Molecules
Subjects:
glycyrrhizic acid
micelles
oral bioavailability
paclitaxel
Online Access:http://www.mdpi.com/1420-3049/20/3/4337

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