Spatial and latent memory data in PS2Tg2576 alzheimer's disease mouse model after memantine treatment

• Main Authors: Masahisa Matsumura, Kana Sato, Takashi Kubota, Yasushi Kishimoto
• Format: Article
• Language: English
• Published: Elsevier 2021-06-01
• Series: Data in Brief
• Subjects: Alzheimer's disease; Latent memory; Memantine; Presenilin 2; Spatial memory
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352340921004157

We herein present behavioral data on whether memantine, an adamantane derivative and medical NMDA-receptor antagonist, improves spatial and latent learning deficits in amyloid precursor protein/presenilin 2 double-transgenic mice (PS2Tg2576 mice). In PS2Tg2576 mice, early amyloid-β protein (Aβ) deposition at 2–3 months of age and progressive accumulation at about 5 months of age has been shown. Thus, PS2Tg2576 mice were subjected to Morris water maze (MWM) test for spatial memory and the water-finding test for latent memory testing at ages 3 and 5–6 months. In addition, memantine (30 mg/kg/day, p.o.) was administered 3–4 weeks before commencing the behavioral tasks to check for effects on cognitive function. The information provided in this paper adds to the literature and can be used for the selection of animal models and behavioral paradigms for Alzheimer's disease (AD) research.