Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural...

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Main Authors:	Bikshapathi Jagga, Megan Edwards, Miriam Pagin, Kylie M. Wagstaff, David Aragão, Noelia Roman, Jeffrey D. Nanson, Shane R. Raidal, Nicole Dominado, Murray Stewart, David A. Jans, Gary R. Hime, Silvia K. Nicolis, Christopher F. Basler, Jade K. Forwood
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20194-0

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spelling	doaj-213cab1ef68b41cbaac148926dd0be5d2021-01-10T12:19:53ZengNature Publishing GroupNature Communications2041-17232021-01-0112111110.1038/s41467-020-20194-0Structural basis for nuclear import selectivity of pioneer transcription factor SOX2Bikshapathi Jagga0Megan Edwards1Miriam Pagin2Kylie M. Wagstaff3David Aragão4Noelia Roman5Jeffrey D. Nanson6Shane R. Raidal7Nicole Dominado8Murray Stewart9David A. Jans10Gary R. Hime11Silvia K. Nicolis12Christopher F. Basler13Jade K. Forwood14School of Biomedical Sciences, Charles Sturt UniversityCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State UniversityDepartment of Biotechnology and Biosciences, University of Milano-BicoccaBiomedicine Discovery Institute, Monash UniversityDiamond Light Source, Harwell Science and Innovation CampusSchool of Biomedical Sciences, Charles Sturt UniversitySchool of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of QueenslandSchool of Animal and Veterinary Sciences, Charles Sturt UniversityDepartment of Anatomy and Neuroscience, University of MelbourneMRC Laboratory of Molecular Biology, Francis Crick Ave., Cambridge Biomedical CampusBiomedicine Discovery Institute, Monash UniversityDepartment of Anatomy and Neuroscience, University of MelbourneDepartment of Biotechnology and Biosciences, University of Milano-BicoccaCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State UniversitySchool of Biomedical Sciences, Charles Sturt UniversityThe SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural basis for the preference of SOX2 binding to IMPα3.https://doi.org/10.1038/s41467-020-20194-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bikshapathi Jagga Megan Edwards Miriam Pagin Kylie M. Wagstaff David Aragão Noelia Roman Jeffrey D. Nanson Shane R. Raidal Nicole Dominado Murray Stewart David A. Jans Gary R. Hime Silvia K. Nicolis Christopher F. Basler Jade K. Forwood
spellingShingle	Bikshapathi Jagga Megan Edwards Miriam Pagin Kylie M. Wagstaff David Aragão Noelia Roman Jeffrey D. Nanson Shane R. Raidal Nicole Dominado Murray Stewart David A. Jans Gary R. Hime Silvia K. Nicolis Christopher F. Basler Jade K. Forwood Structural basis for nuclear import selectivity of pioneer transcription factor SOX2 Nature Communications
author_facet	Bikshapathi Jagga Megan Edwards Miriam Pagin Kylie M. Wagstaff David Aragão Noelia Roman Jeffrey D. Nanson Shane R. Raidal Nicole Dominado Murray Stewart David A. Jans Gary R. Hime Silvia K. Nicolis Christopher F. Basler Jade K. Forwood
author_sort	Bikshapathi Jagga
title	Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
title_short	Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
title_full	Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
title_fullStr	Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
title_full_unstemmed	Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
title_sort	structural basis for nuclear import selectivity of pioneer transcription factor sox2
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural basis for the preference of SOX2 binding to IMPα3.
url	https://doi.org/10.1038/s41467-020-20194-0
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Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

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