Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats
The aim of this research is to evaluate whether posttraining systemic epinephrine is able to improve object recognition memory in rats with memory deficits produced by traumatic brain injury. Forty-nine two-month-old naïve male Wistar rats were submitted to surgical procedures to induce traumatic br...
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Online Access: | http://dx.doi.org/10.1155/2016/9151490 |
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doaj-21414b5ed8534a88851ec75d855d8c982020-11-24T21:28:58ZengHindawi LimitedScientifica2090-908X2016-01-01201610.1155/2016/91514909151490Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in RatsAlejandro Lorón-Sánchez0Meritxell Torras-Garcia1Margalida Coll-Andreu2David Costa-Miserachs3Isabel Portell-Cortés4Departament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, 08193 Bellaterra, Barcelona, SpainDepartament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, 08193 Bellaterra, Barcelona, SpainDepartament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, 08193 Bellaterra, Barcelona, SpainDepartament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, 08193 Bellaterra, Barcelona, SpainDepartament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, 08193 Bellaterra, Barcelona, SpainThe aim of this research is to evaluate whether posttraining systemic epinephrine is able to improve object recognition memory in rats with memory deficits produced by traumatic brain injury. Forty-nine two-month-old naïve male Wistar rats were submitted to surgical procedures to induce traumatic brain injury (TBI) or were sham-operated. Rats were trained in an object recognition task and, immediately after training, received an intraperitoneal injection of distilled water (Sham-Veh and TBI-Veh group) or 0.01 mg/kg epinephrine (TBI-Epi group) or no injection (TBI-0 and Sham-0 groups). Retention was tested 3 h and 24 h after acquisition. The results showed that brain injury produced severe memory deficits and that posttraining administration of epinephrine was able to reverse them. Systemic administration of distilled water also had an enhancing effect, but of a lower magnitude. These data indicate that posttraining epinephrine and, to a lesser extent, vehicle injection reduce memory deficits associated with TBI, probably through induction of a low-to-moderate emotional arousal.http://dx.doi.org/10.1155/2016/9151490 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alejandro Lorón-Sánchez Meritxell Torras-Garcia Margalida Coll-Andreu David Costa-Miserachs Isabel Portell-Cortés |
spellingShingle |
Alejandro Lorón-Sánchez Meritxell Torras-Garcia Margalida Coll-Andreu David Costa-Miserachs Isabel Portell-Cortés Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats Scientifica |
author_facet |
Alejandro Lorón-Sánchez Meritxell Torras-Garcia Margalida Coll-Andreu David Costa-Miserachs Isabel Portell-Cortés |
author_sort |
Alejandro Lorón-Sánchez |
title |
Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats |
title_short |
Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats |
title_full |
Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats |
title_fullStr |
Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats |
title_full_unstemmed |
Posttraining Epinephrine Reverses Memory Deficits Produced by Traumatic Brain Injury in Rats |
title_sort |
posttraining epinephrine reverses memory deficits produced by traumatic brain injury in rats |
publisher |
Hindawi Limited |
series |
Scientifica |
issn |
2090-908X |
publishDate |
2016-01-01 |
description |
The aim of this research is to evaluate whether posttraining systemic epinephrine is able to improve object recognition memory in rats with memory deficits produced by traumatic brain injury. Forty-nine two-month-old naïve male Wistar rats were submitted to surgical procedures to induce traumatic brain injury (TBI) or were sham-operated. Rats were trained in an object recognition task and, immediately after training, received an intraperitoneal injection of distilled water (Sham-Veh and TBI-Veh group) or 0.01 mg/kg epinephrine (TBI-Epi group) or no injection (TBI-0 and Sham-0 groups). Retention was tested 3 h and 24 h after acquisition. The results showed that brain injury produced severe memory deficits and that posttraining administration of epinephrine was able to reverse them. Systemic administration of distilled water also had an enhancing effect, but of a lower magnitude. These data indicate that posttraining epinephrine and, to a lesser extent, vehicle injection reduce memory deficits associated with TBI, probably through induction of a low-to-moderate emotional arousal. |
url |
http://dx.doi.org/10.1155/2016/9151490 |
work_keys_str_mv |
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