Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors
Among the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins. The diverse activities of D2-like receptors are partly mediated by proteins that interac...
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doaj-2144cb40c34c4351a6610ad88599b3ff2020-11-24T21:49:56ZengElsevierJournal of Pharmacological Sciences1347-86132010-01-0111412531Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 ReceptorsNorifumi Shioda0Yusuke Takeuchi1Kohji Fukunaga2Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanAoba Hospital, Uki, Kumamoto 869-0513, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Corresponding author. fukunaga@mail.pharm.tohoku.ac.jpAmong the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins. The diverse activities of D2-like receptors are partly mediated by proteins that interact with the third cytoplasmic loop, which regulate receptor signaling, receptor trafficking, and stability. Furthermore, in the case of D2R and D3R genes, mRNA splicing generates isoforms in the region of the third cytoplasmic loop. The gene encoding D2R gives rise to two isoforms, termed the dopamine D2 receptor long isoform (D2LR) and the dopamine D2 receptor short isoform (D2SR), which lacks 29 amino acids of the D2LR within the third cytoplasmic loop. The D3R gene also produces at least seven distinct alternative splicing variants including D3nf, in which 98 base pairs in the carboxyl-terminal region of the third intracellular loop are deleted. In this review, we focus on proteins interacting with the dopamine D2/D3 receptors in the third cytoplasmic loop. We also define a novel binding protein, heart-type fatty acid–binding protein (H-FABP), which specifically interacts with the 29 D2LR amino acids deleted in D2SR and document its function in D2LR signaling. Keywords:: dopamine D2 receptor, dopamine D3 receptor, alternative splicing variant, heart-type fatty acid–binding protein, catalepsyhttp://www.sciencedirect.com/science/article/pii/S134786131930876X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Norifumi Shioda Yusuke Takeuchi Kohji Fukunaga |
spellingShingle |
Norifumi Shioda Yusuke Takeuchi Kohji Fukunaga Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors Journal of Pharmacological Sciences |
author_facet |
Norifumi Shioda Yusuke Takeuchi Kohji Fukunaga |
author_sort |
Norifumi Shioda |
title |
Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors |
title_short |
Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors |
title_full |
Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors |
title_fullStr |
Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors |
title_full_unstemmed |
Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors |
title_sort |
advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: proteins interacting with the third cytoplasmic loop of dopamine d2 and d3 receptors |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2010-01-01 |
description |
Among the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins. The diverse activities of D2-like receptors are partly mediated by proteins that interact with the third cytoplasmic loop, which regulate receptor signaling, receptor trafficking, and stability. Furthermore, in the case of D2R and D3R genes, mRNA splicing generates isoforms in the region of the third cytoplasmic loop. The gene encoding D2R gives rise to two isoforms, termed the dopamine D2 receptor long isoform (D2LR) and the dopamine D2 receptor short isoform (D2SR), which lacks 29 amino acids of the D2LR within the third cytoplasmic loop. The D3R gene also produces at least seven distinct alternative splicing variants including D3nf, in which 98 base pairs in the carboxyl-terminal region of the third intracellular loop are deleted. In this review, we focus on proteins interacting with the dopamine D2/D3 receptors in the third cytoplasmic loop. We also define a novel binding protein, heart-type fatty acid–binding protein (H-FABP), which specifically interacts with the 29 D2LR amino acids deleted in D2SR and document its function in D2LR signaling. Keywords:: dopamine D2 receptor, dopamine D3 receptor, alternative splicing variant, heart-type fatty acid–binding protein, catalepsy |
url |
http://www.sciencedirect.com/science/article/pii/S134786131930876X |
work_keys_str_mv |
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