NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein...

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Bibliographic Details
Main Authors: Yousuf O Ali, Hunter M Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A Bennett, Philip L De Jager, Joshua M Shulman, Hugo J Bellen, Hui-Chen Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4890852?pdf=render

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