Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact
Abstract Background In a recent article in The Lancet, Protopopoff et al. stated that insecticide resistance must be tackled and concluded that adding the insecticide synergist piperonyl butoxide (PBO) to a bed net with a pyrethroid as principal insecticide might be a part of the response. Main text...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-11-01
|
Series: | Malaria Journal |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12936-018-2596-7 |
id |
doaj-21618ab0f1f44ac58f57ead26603325a |
---|---|
record_format |
Article |
spelling |
doaj-21618ab0f1f44ac58f57ead26603325a2020-11-24T22:04:58ZengBMCMalaria Journal1475-28752018-11-011711310.1186/s12936-018-2596-7Comparing the un-comparable: Olyset Plus and Olyset, different malaria impactOle Skovmand0Intelligent Insect ControlAbstract Background In a recent article in The Lancet, Protopopoff et al. stated that insecticide resistance must be tackled and concluded that adding the insecticide synergist piperonyl butoxide (PBO) to a bed net with a pyrethroid as principal insecticide might be a part of the response. Main text The study in Tanzania compares malaria prevalence between users of two different nets with the principal insecticide permethrin: Olyset and Olyset Plus (Olyset+), the latter also holding the synergist molecule PBO, the first not. The article is based on randomized cluster trial of very high quality, but Olyset+ exposes much more permethrin at the surface so the higher efficacy may not be because of the added PBO. Conclusion Data published by the World Health Organization (WHO) when evaluating Olyset+ as well of the study of Protopopoff et al. showed that much more permethrin is available on the surface of Olyset+ than on the surface of Olyset and the relatively small and rapidly dwindling dosage of PBO may have nothing to do with the superior effect of Olyset+. The WHO should not change politics for “PBO nets” based on this study alone.http://link.springer.com/article/10.1186/s12936-018-2596-7Bed netInsecticide resistanceOlyset PlusPermethrinWHO |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ole Skovmand |
spellingShingle |
Ole Skovmand Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact Malaria Journal Bed net Insecticide resistance Olyset Plus Permethrin WHO |
author_facet |
Ole Skovmand |
author_sort |
Ole Skovmand |
title |
Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact |
title_short |
Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact |
title_full |
Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact |
title_fullStr |
Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact |
title_full_unstemmed |
Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact |
title_sort |
comparing the un-comparable: olyset plus and olyset, different malaria impact |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2018-11-01 |
description |
Abstract Background In a recent article in The Lancet, Protopopoff et al. stated that insecticide resistance must be tackled and concluded that adding the insecticide synergist piperonyl butoxide (PBO) to a bed net with a pyrethroid as principal insecticide might be a part of the response. Main text The study in Tanzania compares malaria prevalence between users of two different nets with the principal insecticide permethrin: Olyset and Olyset Plus (Olyset+), the latter also holding the synergist molecule PBO, the first not. The article is based on randomized cluster trial of very high quality, but Olyset+ exposes much more permethrin at the surface so the higher efficacy may not be because of the added PBO. Conclusion Data published by the World Health Organization (WHO) when evaluating Olyset+ as well of the study of Protopopoff et al. showed that much more permethrin is available on the surface of Olyset+ than on the surface of Olyset and the relatively small and rapidly dwindling dosage of PBO may have nothing to do with the superior effect of Olyset+. The WHO should not change politics for “PBO nets” based on this study alone. |
topic |
Bed net Insecticide resistance Olyset Plus Permethrin WHO |
url |
http://link.springer.com/article/10.1186/s12936-018-2596-7 |
work_keys_str_mv |
AT oleskovmand comparingtheuncomparableolysetplusandolysetdifferentmalariaimpact |
_version_ |
1725827918821588992 |