It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells
Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional immune subset acting at the interface of inna...
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doaj-2170c9a049744114ab34003a56c2be8d2020-11-24T23:13:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01489390991It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T CellsCéline Mortier0Céline Mortier1Srinath Govindarajan2Srinath Govindarajan3Koen Venken4Koen Venken5Dirk Elewaut6Dirk Elewaut7Department of Rheumatology, Ghent University Hospital, Ghent, BelgiumUnit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research, Ghent University, Ghent, BelgiumDepartment of Rheumatology, Ghent University Hospital, Ghent, BelgiumUnit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research, Ghent University, Ghent, BelgiumDepartment of Rheumatology, Ghent University Hospital, Ghent, BelgiumUnit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research, Ghent University, Ghent, BelgiumDepartment of Rheumatology, Ghent University Hospital, Ghent, BelgiumUnit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research, Ghent University, Ghent, BelgiumInnate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional immune subset acting at the interface of innate and adaptive immunity. Highly represented at barrier sites and capable of rapidly producing substantial amounts of cytokines, they serve a pivotal role as first-line responders against microbial infections. In contrast, it was demonstrated that innate-like T cells can be skewed toward a predominant pro-inflammatory state and are consequently involved in a number of autoimmune and inflammatory diseases like inflammatory bowel diseases and rheumatic disorders, such as spondyloarthritis (SpA) and rheumatoid arthritis. Interestingly, there is link between gut and joint disease as they often co-incide and share certain aspects of the pathogenesis such as established genetic risk factors, a critical role for pro-inflammatory cytokines, such as TNF-α, IL-23, and IL-17 and therapeutic susceptibility. In this regard dysregulated IL-23/IL-17 responses appear to be crucial in both debilitating pathologies and innate-like T cells likely act as key player. In this review, we will explore the remarkable features of iNKT cells and MAIT cells, and discuss their contribution to immunity and combined gut–joint disease.https://www.frontiersin.org/article/10.3389/fimmu.2018.01489/fullinnate-like T cellsinvariant natural killer T cellsmucosal-associated invariant T cellsCD1MR1rheumatic diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Céline Mortier Céline Mortier Srinath Govindarajan Srinath Govindarajan Koen Venken Koen Venken Dirk Elewaut Dirk Elewaut |
spellingShingle |
Céline Mortier Céline Mortier Srinath Govindarajan Srinath Govindarajan Koen Venken Koen Venken Dirk Elewaut Dirk Elewaut It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells Frontiers in Immunology innate-like T cells invariant natural killer T cells mucosal-associated invariant T cells CD1 MR1 rheumatic diseases |
author_facet |
Céline Mortier Céline Mortier Srinath Govindarajan Srinath Govindarajan Koen Venken Koen Venken Dirk Elewaut Dirk Elewaut |
author_sort |
Céline Mortier |
title |
It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells |
title_short |
It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells |
title_full |
It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells |
title_fullStr |
It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells |
title_full_unstemmed |
It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells |
title_sort |
it takes “guts” to cause joint inflammation: role of innate-like t cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-06-01 |
description |
Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional immune subset acting at the interface of innate and adaptive immunity. Highly represented at barrier sites and capable of rapidly producing substantial amounts of cytokines, they serve a pivotal role as first-line responders against microbial infections. In contrast, it was demonstrated that innate-like T cells can be skewed toward a predominant pro-inflammatory state and are consequently involved in a number of autoimmune and inflammatory diseases like inflammatory bowel diseases and rheumatic disorders, such as spondyloarthritis (SpA) and rheumatoid arthritis. Interestingly, there is link between gut and joint disease as they often co-incide and share certain aspects of the pathogenesis such as established genetic risk factors, a critical role for pro-inflammatory cytokines, such as TNF-α, IL-23, and IL-17 and therapeutic susceptibility. In this regard dysregulated IL-23/IL-17 responses appear to be crucial in both debilitating pathologies and innate-like T cells likely act as key player. In this review, we will explore the remarkable features of iNKT cells and MAIT cells, and discuss their contribution to immunity and combined gut–joint disease. |
topic |
innate-like T cells invariant natural killer T cells mucosal-associated invariant T cells CD1 MR1 rheumatic diseases |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01489/full |
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