Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches
There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal thr...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Micromachines |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-666X/11/6/610 |
id |
doaj-21792ab3e3b34194801f293b843c6be0 |
---|---|
record_format |
Article |
spelling |
doaj-21792ab3e3b34194801f293b843c6be02020-11-25T02:17:22ZengMDPI AGMicromachines2072-666X2020-06-011161061010.3390/mi11060610Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up ApproachesTaisuke Shimada0Takao Yasui1Akihiro Yonese2Takeshi Yanagida3Noritada Kaji4Masaki Kanai5Kazuki Nagashima6Tomoji Kawai7Yoshinobu Baba8Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanDepartment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanDepartment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, JapanInstitute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanInstitute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, JapanJapan Science and Technology Agency (JST), PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, JapanThe Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, JapanDepartment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanThere are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal three-dimensional structures. Herein, we developed ZnO/SiO<sub>2</sub> nanowire structures by using bottom-up approaches and demonstrated to show mechanical rupture-based antibacterial activity and compatibility with human cells. When <i>Escherichia coli</i> were cultured on the surface for 24 h, over 99% of the bacteria were inactivated, while more than 80% of HeLa cells that were cultured on the surface for 24 h were still alive. This is the first demonstration of mechanical rupture-based bacterial rupture via the hydrothermally synthesized nanowire structures with antibacterial activity and cell compatibility.https://www.mdpi.com/2072-666X/11/6/610nanowire structureshydrothermal synthesismechanical-based ruptureantibacterial activitycell compatibility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taisuke Shimada Takao Yasui Akihiro Yonese Takeshi Yanagida Noritada Kaji Masaki Kanai Kazuki Nagashima Tomoji Kawai Yoshinobu Baba |
spellingShingle |
Taisuke Shimada Takao Yasui Akihiro Yonese Takeshi Yanagida Noritada Kaji Masaki Kanai Kazuki Nagashima Tomoji Kawai Yoshinobu Baba Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches Micromachines nanowire structures hydrothermal synthesis mechanical-based rupture antibacterial activity cell compatibility |
author_facet |
Taisuke Shimada Takao Yasui Akihiro Yonese Takeshi Yanagida Noritada Kaji Masaki Kanai Kazuki Nagashima Tomoji Kawai Yoshinobu Baba |
author_sort |
Taisuke Shimada |
title |
Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches |
title_short |
Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches |
title_full |
Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches |
title_fullStr |
Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches |
title_full_unstemmed |
Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO<sub>2</sub> Nanowire Structures Formed by Bottom-Up Approaches |
title_sort |
mechanical rupture-based antibacterial and cell-compatible zno/sio<sub>2</sub> nanowire structures formed by bottom-up approaches |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2020-06-01 |
description |
There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal three-dimensional structures. Herein, we developed ZnO/SiO<sub>2</sub> nanowire structures by using bottom-up approaches and demonstrated to show mechanical rupture-based antibacterial activity and compatibility with human cells. When <i>Escherichia coli</i> were cultured on the surface for 24 h, over 99% of the bacteria were inactivated, while more than 80% of HeLa cells that were cultured on the surface for 24 h were still alive. This is the first demonstration of mechanical rupture-based bacterial rupture via the hydrothermally synthesized nanowire structures with antibacterial activity and cell compatibility. |
topic |
nanowire structures hydrothermal synthesis mechanical-based rupture antibacterial activity cell compatibility |
url |
https://www.mdpi.com/2072-666X/11/6/610 |
work_keys_str_mv |
AT taisukeshimada mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT takaoyasui mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT akihiroyonese mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT takeshiyanagida mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT noritadakaji mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT masakikanai mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT kazukinagashima mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT tomojikawai mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches AT yoshinobubaba mechanicalrupturebasedantibacterialandcellcompatibleznosiosub2subnanowirestructuresformedbybottomupapproaches |
_version_ |
1724886810428964864 |