Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery
Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MF...
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doaj-217d81abb0b34f15ae788cff602876c02020-11-24T23:59:39ZengHindawi LimitedAdvances in Materials Science and Engineering1687-84341687-84422015-01-01201510.1155/2015/180187180187Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen DeliveryToan Tran0Mariana Hernandez1Dhruvil Patel2Ji Wu3Department of Chemistry, Georgia Southern University, 250 Forest Drive, Statesboro, GA 30460, USADepartment of Chemistry, Georgia Southern University, 250 Forest Drive, Statesboro, GA 30460, USADepartment of Chemistry, Georgia Southern University, 250 Forest Drive, Statesboro, GA 30460, USADepartment of Chemistry, Georgia Southern University, 250 Forest Drive, Statesboro, GA 30460, USAElectrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH. The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pH was lower than the pKa of carboxylic acids (pH 2). At room temperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH. Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery.http://dx.doi.org/10.1155/2015/180187 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toan Tran Mariana Hernandez Dhruvil Patel Ji Wu |
spellingShingle |
Toan Tran Mariana Hernandez Dhruvil Patel Ji Wu Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery Advances in Materials Science and Engineering |
author_facet |
Toan Tran Mariana Hernandez Dhruvil Patel Ji Wu |
author_sort |
Toan Tran |
title |
Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery |
title_short |
Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery |
title_full |
Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery |
title_fullStr |
Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery |
title_full_unstemmed |
Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery |
title_sort |
temperature and ph responsive microfibers for controllable and variable ibuprofen delivery |
publisher |
Hindawi Limited |
series |
Advances in Materials Science and Engineering |
issn |
1687-8434 1687-8442 |
publishDate |
2015-01-01 |
description |
Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH. The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pH was lower than the pKa of carboxylic acids (pH 2). At room temperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH. Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery. |
url |
http://dx.doi.org/10.1155/2015/180187 |
work_keys_str_mv |
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