RESTORATION OF FERTILITY IN A MAN WITH AZOOSPERMIA DEVELOPED IN RESPONSE TO TREATMENT WITH TESTOSTERONE GEL (A CASE REPORT)

• Main Authors: I. A. Korneev, R. D. Zaseev, O. I. Zabelkina
• Format: Article
• Language: Russian
• Published: ABV-press 2017-11-01
• Series: Andrologiâ i Genitalʹnaâ Hirurgiâ
• Subjects: hormone replacement therapy; testosterone; infertility; azoospermia
• Online Access: https://agx.abvpress.ru/jour/article/view/249

Testosterone replacement therapy (TRT) allows to combat the symptoms of age-related androgen deficiency (AAD); however, it may have side effects, including the reduction in sperm count and even complete cessation of spermatogenesis and development of azoospermia. The fertility may not be restored even within 18 month after treatment completion. Russian researcher explored the impact of TRT with gel on the ejaculate parameters in men with hypogonadism and observed no negative effects on spermatogenesis within 3 months after treatment initiation. We describe a clinical case of reversible azoospermia induced by a relatively short course of TRT with gel. Fertilizing capacity of sperm was finally restored, which was confirmed by a clinical pregnancy obtained by in vitro fertilization. Physicians prescribing TRT should inform their patients that such treatment is contraindicated to those men who would like to preserve their fertility and explain that the restoration of fertility will take some time after treatment completion.