The association of DNA Repair with breast cancer risk in women. A comparative observational study
<p>Abstract</p> <p>Background</p> <p>Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological st...
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doaj-218655958835493b95ba0b8f630117232020-11-24T23:05:19ZengBMCBMC Cancer1471-24072012-10-0112149010.1186/1471-2407-12-490The association of DNA Repair with breast cancer risk in women. A comparative observational studyMatta JaimeEchenique MiguelNegron EsperanzaMorales LuisaVargas WandaGaetan Felipe SánchezLizardi Eduardo RamírezTorres AníbalRosado Jose OrtizBolaños GuillermoCruz Juan GonzálezLaboy JoaquínBarnes RicardoMedina Santos SantiagoRomero ÁngelMartinez RosendoDutil JulieSuarez ErickAlvarez-Garriga CarolinaBayona Manuel<p>Abstract</p> <p>Background</p> <p>Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community.</p> <p>Methods</p> <p>We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.</p> <p>Results</p> <p>Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (<it>p</it> < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (<it>p</it> < 0.0001).</p> <p>Conclusions</p> <p>Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.</p> http://www.biomedcentral.com/1471-2407/12/490Breast cancerDNA repair capacityAssociationRiskBiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matta Jaime Echenique Miguel Negron Esperanza Morales Luisa Vargas Wanda Gaetan Felipe Sánchez Lizardi Eduardo Ramírez Torres Aníbal Rosado Jose Ortiz Bolaños Guillermo Cruz Juan González Laboy Joaquín Barnes Ricardo Medina Santos Santiago Romero Ángel Martinez Rosendo Dutil Julie Suarez Erick Alvarez-Garriga Carolina Bayona Manuel |
spellingShingle |
Matta Jaime Echenique Miguel Negron Esperanza Morales Luisa Vargas Wanda Gaetan Felipe Sánchez Lizardi Eduardo Ramírez Torres Aníbal Rosado Jose Ortiz Bolaños Guillermo Cruz Juan González Laboy Joaquín Barnes Ricardo Medina Santos Santiago Romero Ángel Martinez Rosendo Dutil Julie Suarez Erick Alvarez-Garriga Carolina Bayona Manuel The association of DNA Repair with breast cancer risk in women. A comparative observational study BMC Cancer Breast cancer DNA repair capacity Association Risk Biomarker |
author_facet |
Matta Jaime Echenique Miguel Negron Esperanza Morales Luisa Vargas Wanda Gaetan Felipe Sánchez Lizardi Eduardo Ramírez Torres Aníbal Rosado Jose Ortiz Bolaños Guillermo Cruz Juan González Laboy Joaquín Barnes Ricardo Medina Santos Santiago Romero Ángel Martinez Rosendo Dutil Julie Suarez Erick Alvarez-Garriga Carolina Bayona Manuel |
author_sort |
Matta Jaime |
title |
The association of DNA Repair with breast cancer risk in women. A comparative observational study |
title_short |
The association of DNA Repair with breast cancer risk in women. A comparative observational study |
title_full |
The association of DNA Repair with breast cancer risk in women. A comparative observational study |
title_fullStr |
The association of DNA Repair with breast cancer risk in women. A comparative observational study |
title_full_unstemmed |
The association of DNA Repair with breast cancer risk in women. A comparative observational study |
title_sort |
association of dna repair with breast cancer risk in women. a comparative observational study |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2012-10-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community.</p> <p>Methods</p> <p>We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.</p> <p>Results</p> <p>Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (<it>p</it> < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (<it>p</it> < 0.0001).</p> <p>Conclusions</p> <p>Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.</p> |
topic |
Breast cancer DNA repair capacity Association Risk Biomarker |
url |
http://www.biomedcentral.com/1471-2407/12/490 |
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