Experimental and Theoretical Study on Theobromine Solubility Enhancement in Binary Aqueous Solutions and Ternary Designed Solvents

Experimental and Theoretical Study on Theobromine Solubility Enhancement in Binary Aqueous Solutions and Ternary Designed Solvents

The solubility of theobromine was studied both experimentally and theoretically. The solubility was determined spectrophotometrically at 25 °C in neat organic solvents, aqueous binary mixtures, Natural Deep Eutectic Solvents (NADES) and ternary NADES mixtures with water. It was found that addition o...

Full description

Bibliographic Details
Main Authors:	Tomasz Jeliński, Dawid Stasiak, Tomasz Kosmalski, Piotr Cysewski
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Pharmaceutics
Subjects:	theobromine solubility COSMO-RS NADES methylxanthines
Online Access:	https://www.mdpi.com/1999-4923/13/8/1118

Similar Items

Solvent Screening for Solubility Enhancement of Theophylline in Neat, Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning
by: Piotr Cysewski, et al.
Published: (2021-07-01)

3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2
by: Binxing Zhou, et al.
Published: (2020-08-01)

Production of 7-methylxanthine from Theobromine by Metabolically Engineered E. coli
by: Khalid Hussein Rheima Algharrawi, et al.
Published: (2020-09-01)

Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells
by: Daniel Janitschke, et al.
Published: (2020-11-01)

Application of the Consonance Solvent Concept for Accurate Prediction of Buckminster Solubility in 180 Net Solvents using COSMO-RS Approach
by: Piotr Cysewski
Published: (2019-06-01)

Methylxanthines and Neurodegenerative Diseases: An Update
by: Daniel Janitschke, et al.
Published: (2021-02-01)

Untersuchungen zur Pharmakokinetik von Coffein, Theophyllin und Theobromin beim Hund nach Aufnahme von Kaffee, Tee und Schokolade
by: Loeffler, Bernd Matthias Nikolaus
Published: (2004)

Methylxanthine Content in Commonly Consumed Foods in Spain and Determination of Its Intake during Consumption
by: Juan M. Sanchez
Published: (2017-12-01)

Methylxanthines accumulation in Ilex species - caffeine and theobromine in erva-mate (Ilex paraguariensis) and other Ilex species
by: Reginatto F.H., et al.
Published: (1999-01-01)

Effect of theobromine in antimicrobial activity: An in vitro study
by: Arthi Lakshmi, et al.
Published: (2019-01-01)

Temperature Effect of the Theobromine’s Electronic and Antioxidant Properties
by: Aslı Öztürk Kiraz
Published: (2019-03-01)

Application of COSMO-SAC to Solid Solubility in Pure and Mixed Solvent Mixtures for Organic Pharmacological Compounds
by: Mullins, Paul Eric
Published: (2014)

Phenolic and Theobromine Contents of Commercial Dark, Milk and White Chocolates on the Malaysian Market
by: Cheng Chia Meng, et al.
Published: (2009-01-01)

Synthesis and physical-chemical properties of 8-benzylidenhydrazino-1-(4-fluorobenzyl)theobromine derivatives
by: D. G. Ivanchenko, et al.
Published: (2014-12-01)

Graphene Oxide: A Smart (Starting) Material for Natural Methylxanthines Adsorption and Detection
by: Rita Petrucci, et al.
Published: (2019-11-01)

Artificial Caries Lesion Characteristics after Secondary Demineralization with Theobromine-Containing Protocol
by: Hani M. Nassar, et al.
Published: (2021-01-01)

PENGARUH KONSENTRASI GEL THEOBROMINE TERHADAP KETAHANAN KEKERASAN PERMUKAAN EMAIL GIGI DESIDUI
by: indah lestari vidyahayati, et al.
Published: (2019-07-01)

The relevance of theobromine for the beneficial effects of cocoa consumption
by: Eva eMartínez-Pinilla, et al.
Published: (2015-02-01)

PENGARUH APLIKASI GEL THEOBROMINE TERHADAP KEKASARAN PERMUKAAN EMAIL GIGI DESIDUI PASCA DEMINERALISASI
by: Shoimah Alfa Makmur, et al.
Published: (2019-12-01)

METHYLXANTHINE LEVELS IN BREAST MILK OF LACTATING WOMEN OF DIFFERENT SOCIOECONOMIC CLASSES (CAFFEINE, THEOBROMINE, PARAXANTHINE, THEOPHYLLINE, ETHNIC).
by: Shearer, Luz-Elena Oropesa.
Published: (1985)

Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine
by: Yumaira Hernandez, et al.
Published: (2020-07-01)

Effect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations
by: Doris M. Jacobs, et al.
Published: (2017-08-01)

Supercritical Fluid Extraction of Fat and Caffeine with Theobromine Retention in the Cocoa Shell
by: Fanny Adabel González-Alejo, et al.
Published: (2019-06-01)

Study of the toluene absorption capacity and mechanism of ionic liquids using COSMO-RS prediction and experimental verification
by: Chenglong Zhang, et al.
Published: (2021-06-01)

Efficacy of Theobromine and Sodium Fluoride Solutions for Remineralization of Initial Enamel Caries Lesions
by: Farnaz Farhad, et al.
Published: (2021-04-01)

Synthesis and Biological Evaluation of Structurally Varied 5′-/6′-Isonucleosides and Theobromine-Containing <i>N</i>-Isonucleosidyl Derivatives
by: Nuno M. Xavier, et al.
Published: (2019-07-01)

Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model
by: Sara Shojaei-Zarghani, et al.
Published: (2021-02-01)

Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations
by: Piotr Cysewski, et al.
Published: (2021-07-01)

Proximate Composition, Extraction, and Purification of Theobromine from Cacao Pod Husk (Theobroma Cacao L.)
by: Van Tang Nguyen, et al.
Published: (2017-04-01)

Analysis of Theobromine and Related Compounds by Reversed Phase High-Performance Liquid Chromatography with Ultraviolet Detection: An Update (1992–2011)
by: Sandra Aparecida de Assis, et al.
Published: (2011-01-01)

Ionic liquids/deep eutectic solvents for CO2 capture: Reviewing and evaluating
by: Yanrong Liu, et al.
Published: (2021-06-01)

Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
by: Rafiad Islam, et al.
Published: (2019-04-01)

Screening Deep Eutectic Solvents for CO2 Capture With COSMO-RS
by: Yanrong Liu, et al.
Published: (2020-02-01)

Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells
by: Daniel Janitschke, et al.
Published: (2019-11-01)

Experimental approach versus COSMO-RS assisted solvent screening for predicting the solubility of rapeseed oil
by: Sicaire Anne-Gaëlle, et al.
Published: (2015-07-01)

Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals
by: Marta Faggian, et al.
Published: (2016-11-01)

Synthesis, physical-chemical and biological properties of 1,8-disubstituted compounds of theobromine. III. 8-Amino-p-chlorobenzyltheobromines
by: D. G. Ivanchenko, et al.
Published: (2014-08-01)

Keratin Extraction from Wool and Feathers Using Natural Deep Eutectic Solvents
by: Eliza-Gabriela Mihăilă, et al.
Published: (2019-10-01)

Natural Deep Eutectic Solvents (NADES) to Enhance Berberine Absorption: An In Vivo Pharmacokinetic Study
by: Stefania Sut, et al.
Published: (2017-11-01)

Carbon Dioxide Solubility in Nonionic Deep Eutectic Solvents Containing Phenolic Alcohols
by: Alhadid, A., et al.
Published: (2022)