Lymphatic Connexins and Pannexins in Health and Disease
This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of th...
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doaj-2193825301ca4cc0bace4ec443c3ba5e2021-06-01T01:21:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225734573410.3390/ijms22115734Lymphatic Connexins and Pannexins in Health and DiseaseAvigail Ehrlich0Filippo Molica1Aurélie Hautefort2Brenda R. Kwak3Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, University of Geneva, CH-1211 Geneva, SwitzerlandThis review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic system. We describe their influence on the maintenance of extracellular fluid homeostasis, immune cell trafficking to draining lymph nodes and dietary nutrient absorption by intestinal villi. Moreover, new insights into connexin mutations in primary and secondary lymphedema as well as on the implication of lymphatic connexins and pannexins in acquired cardiovascular diseases are discussed, allowing for a better understanding of the role of these proteins in pathologies linked to dysfunctions in the lymphatic system.https://www.mdpi.com/1422-0067/22/11/5734gap junctionconnexinpannexinlymphatic vasculaturelymphedema |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Avigail Ehrlich Filippo Molica Aurélie Hautefort Brenda R. Kwak |
spellingShingle |
Avigail Ehrlich Filippo Molica Aurélie Hautefort Brenda R. Kwak Lymphatic Connexins and Pannexins in Health and Disease International Journal of Molecular Sciences gap junction connexin pannexin lymphatic vasculature lymphedema |
author_facet |
Avigail Ehrlich Filippo Molica Aurélie Hautefort Brenda R. Kwak |
author_sort |
Avigail Ehrlich |
title |
Lymphatic Connexins and Pannexins in Health and Disease |
title_short |
Lymphatic Connexins and Pannexins in Health and Disease |
title_full |
Lymphatic Connexins and Pannexins in Health and Disease |
title_fullStr |
Lymphatic Connexins and Pannexins in Health and Disease |
title_full_unstemmed |
Lymphatic Connexins and Pannexins in Health and Disease |
title_sort |
lymphatic connexins and pannexins in health and disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic system. We describe their influence on the maintenance of extracellular fluid homeostasis, immune cell trafficking to draining lymph nodes and dietary nutrient absorption by intestinal villi. Moreover, new insights into connexin mutations in primary and secondary lymphedema as well as on the implication of lymphatic connexins and pannexins in acquired cardiovascular diseases are discussed, allowing for a better understanding of the role of these proteins in pathologies linked to dysfunctions in the lymphatic system. |
topic |
gap junction connexin pannexin lymphatic vasculature lymphedema |
url |
https://www.mdpi.com/1422-0067/22/11/5734 |
work_keys_str_mv |
AT avigailehrlich lymphaticconnexinsandpannexinsinhealthanddisease AT filippomolica lymphaticconnexinsandpannexinsinhealthanddisease AT aureliehautefort lymphaticconnexinsandpannexinsinhealthanddisease AT brendarkwak lymphaticconnexinsandpannexinsinhealthanddisease |
_version_ |
1721412521878880256 |