Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaust...

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Main Authors:	David H. Peng, Bertha Leticia Rodriguez, Lixia Diao, Limo Chen, Jing Wang, Lauren A. Byers, Ying Wei, Harold A. Chapman, Mitsuo Yamauchi, Carmen Behrens, Gabriela Raso, Luisa Maren Solis Soto, Edwin Roger Parra Cuentes, Ignacio I. Wistuba, Jonathan M. Kurie, Don L. Gibbons
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18298-8

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spelling	doaj-219973ddbc6547bdba9bd0531b756cc72021-09-12T11:47:52ZengNature Publishing GroupNature Communications2041-17232020-09-0111111810.1038/s41467-020-18298-8Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustionDavid H. Peng0Bertha Leticia Rodriguez1Lixia Diao2Limo Chen3Jing Wang4Lauren A. Byers5Ying Wei6Harold A. Chapman7Mitsuo Yamauchi8Carmen Behrens9Gabriela Raso10Luisa Maren Solis Soto11Edwin Roger Parra Cuentes12Ignacio I. Wistuba13Jonathan M. Kurie14Don L. Gibbons15Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Medicine, UCSF Cardiovascular Research InstituteDepartment of Medicine, UCSF Cardiovascular Research InstituteOral and Craniofacial Health Sciences, University of North Carolina at Chapel HillDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterTumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.https://doi.org/10.1038/s41467-020-18298-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons
spellingShingle	David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion Nature Communications
author_facet	David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons
author_sort	David H. Peng
title	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_short	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_full	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_fullStr	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_full_unstemmed	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_sort	collagen promotes anti-pd-1/pd-l1 resistance in cancer through lair1-dependent cd8+ t cell exhaustion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.
url	https://doi.org/10.1038/s41467-020-18298-8
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Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

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