Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaust...
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2020-09-01
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Online Access: | https://doi.org/10.1038/s41467-020-18298-8 |
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doaj-219973ddbc6547bdba9bd0531b756cc72021-09-12T11:47:52ZengNature Publishing GroupNature Communications2041-17232020-09-0111111810.1038/s41467-020-18298-8Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustionDavid H. Peng0Bertha Leticia Rodriguez1Lixia Diao2Limo Chen3Jing Wang4Lauren A. Byers5Ying Wei6Harold A. Chapman7Mitsuo Yamauchi8Carmen Behrens9Gabriela Raso10Luisa Maren Solis Soto11Edwin Roger Parra Cuentes12Ignacio I. Wistuba13Jonathan M. Kurie14Don L. Gibbons15Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Medicine, UCSF Cardiovascular Research InstituteDepartment of Medicine, UCSF Cardiovascular Research InstituteOral and Craniofacial Health Sciences, University of North Carolina at Chapel HillDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterTumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.https://doi.org/10.1038/s41467-020-18298-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons |
spellingShingle |
David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion Nature Communications |
author_facet |
David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons |
author_sort |
David H. Peng |
title |
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion |
title_short |
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion |
title_full |
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion |
title_fullStr |
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion |
title_full_unstemmed |
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion |
title_sort |
collagen promotes anti-pd-1/pd-l1 resistance in cancer through lair1-dependent cd8+ t cell exhaustion |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-09-01 |
description |
Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion. |
url |
https://doi.org/10.1038/s41467-020-18298-8 |
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