Neural basis of limb ownership in individuals with body integrity identity disorder.
Our body feels like it is ours. However, individuals with body integrity identity disorder (BIID) lack this feeling of ownership for distinct limbs and desire amputation of perfectly healthy body parts. This extremely rare condition provides us with an opportunity to study the neural basis underlyin...
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doaj-21a423a7233945b089760a16dd09bb132020-11-25T02:35:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7221210.1371/journal.pone.0072212Neural basis of limb ownership in individuals with body integrity identity disorder.Milenna T van DijkGuido A van WingenAnouk van LammerenRianne M BlomBart P de KwaastenietH Steven ScholteDamiaan DenysOur body feels like it is ours. However, individuals with body integrity identity disorder (BIID) lack this feeling of ownership for distinct limbs and desire amputation of perfectly healthy body parts. This extremely rare condition provides us with an opportunity to study the neural basis underlying the feeling of limb ownership, since these individuals have a feeling of disownership for a limb in the absence of apparent brain damage. Here we directly compared brain activation between limbs that do and do not feel as part of the body using functional MRI during separate tactile stimulation and motor execution experiments. In comparison to matched controls, individuals with BIID showed heightened responsivity of a large somatosensory network including the parietal cortex and right insula during tactile stimulation, regardless of whether the stimulated leg felt owned or alienated. Importantly, activity in the ventral premotor cortex depended on the feeling of ownership and was reduced during stimulation of the alienated compared to the owned leg. In contrast, no significant differences between groups were observed during the performance of motor actions. These results suggest that altered somatosensory processing in the premotor cortex is associated with the feeling of disownership in BIID, which may be related to altered integration of somatosensory and proprioceptive information.http://europepmc.org/articles/PMC3749113?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Milenna T van Dijk Guido A van Wingen Anouk van Lammeren Rianne M Blom Bart P de Kwaasteniet H Steven Scholte Damiaan Denys |
spellingShingle |
Milenna T van Dijk Guido A van Wingen Anouk van Lammeren Rianne M Blom Bart P de Kwaasteniet H Steven Scholte Damiaan Denys Neural basis of limb ownership in individuals with body integrity identity disorder. PLoS ONE |
author_facet |
Milenna T van Dijk Guido A van Wingen Anouk van Lammeren Rianne M Blom Bart P de Kwaasteniet H Steven Scholte Damiaan Denys |
author_sort |
Milenna T van Dijk |
title |
Neural basis of limb ownership in individuals with body integrity identity disorder. |
title_short |
Neural basis of limb ownership in individuals with body integrity identity disorder. |
title_full |
Neural basis of limb ownership in individuals with body integrity identity disorder. |
title_fullStr |
Neural basis of limb ownership in individuals with body integrity identity disorder. |
title_full_unstemmed |
Neural basis of limb ownership in individuals with body integrity identity disorder. |
title_sort |
neural basis of limb ownership in individuals with body integrity identity disorder. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Our body feels like it is ours. However, individuals with body integrity identity disorder (BIID) lack this feeling of ownership for distinct limbs and desire amputation of perfectly healthy body parts. This extremely rare condition provides us with an opportunity to study the neural basis underlying the feeling of limb ownership, since these individuals have a feeling of disownership for a limb in the absence of apparent brain damage. Here we directly compared brain activation between limbs that do and do not feel as part of the body using functional MRI during separate tactile stimulation and motor execution experiments. In comparison to matched controls, individuals with BIID showed heightened responsivity of a large somatosensory network including the parietal cortex and right insula during tactile stimulation, regardless of whether the stimulated leg felt owned or alienated. Importantly, activity in the ventral premotor cortex depended on the feeling of ownership and was reduced during stimulation of the alienated compared to the owned leg. In contrast, no significant differences between groups were observed during the performance of motor actions. These results suggest that altered somatosensory processing in the premotor cortex is associated with the feeling of disownership in BIID, which may be related to altered integration of somatosensory and proprioceptive information. |
url |
http://europepmc.org/articles/PMC3749113?pdf=render |
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