Association between the levels of prostaglandin E2 in tears and severity of dry eye
AIM: To investigate the relationship between the levels of prostaglandin E2 (PGE2) in tears and dry eye disease severity based on both clinical symptoms and signs. METHODS: Tear samples were collected from 36 non-Sjögren syndrome dry eye patients (10 males and 26 females, mean age 50.11±11.17y). Al...
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doaj-21a8f52a9d2846e99fcaed3fd60ad7e42020-11-25T01:50:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982019-07-011271127113310.18240/ijo.2019.07.12Association between the levels of prostaglandin E2 in tears and severity of dry eyeKaevalin Lekhanont0Kanchalika Sathianvichitr1Punyanuch Pisitpayat2Thunyarat Anothaisintawee3Kitipong Soontrapa4Umaporn Udomsubpayakul5Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Family Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, ThailandClinical Epidemiology and Biostatistics Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandAIM: To investigate the relationship between the levels of prostaglandin E2 (PGE2) in tears and dry eye disease severity based on both clinical symptoms and signs. METHODS: Tear samples were collected from 36 non-Sjögren syndrome dry eye patients (10 males and 26 females, mean age 50.11±11.17y). All participants completed the Ocular Surface Disease Index (OSDI) questionnaire and underwent a detailed ophthalmic examination including, tear film breakup time (TBUT), ocular surface fluorescein staining, Schirmer I test, and meibomian gland assessment. The level of PGE2 in tears was measured using enzyme-linked immunosorbent assay (ELISA). The independent associations between tear PGE2 levels and other variables including demographics, OSDI scores, TBUT, Schirmer scores, ocular surface staining scores, and stage of meibomian gland dysfunction (MGD) were evaluated using linear regression analysis. RESULTS: The mean PGE2 level in tears of dry eye patients was 537.85±234.02 pg/mL. The tear PGE2 levels significantly positively correlated with OSDI scores (R=0.608, P<0.001), however, they did not significantly associate with TBUT (R=0.153, P=0.373), Schirmer scores (R=-0.098, P=0.570), ocular surface staining scores (R=0.282, P=0.095), and stage of MGD (R=-0.107, P=0.535). Male sex was significantly negatively correlated with tear PGE2 levels. CONCLUSION: The levels of PGE2 in tears are positively correlated with dry eye symptoms. However, no significant association was found between tear PGE2 levels and the results of other common dry eye diagnostic tests.http://www.ijo.cn/en_publish/2019/7/20190712.pdfdry eyeprostaglandin e2severityteardry eye tests |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kaevalin Lekhanont Kanchalika Sathianvichitr Punyanuch Pisitpayat Thunyarat Anothaisintawee Kitipong Soontrapa Umaporn Udomsubpayakul |
spellingShingle |
Kaevalin Lekhanont Kanchalika Sathianvichitr Punyanuch Pisitpayat Thunyarat Anothaisintawee Kitipong Soontrapa Umaporn Udomsubpayakul Association between the levels of prostaglandin E2 in tears and severity of dry eye International Journal of Ophthalmology dry eye prostaglandin e2 severity tear dry eye tests |
author_facet |
Kaevalin Lekhanont Kanchalika Sathianvichitr Punyanuch Pisitpayat Thunyarat Anothaisintawee Kitipong Soontrapa Umaporn Udomsubpayakul |
author_sort |
Kaevalin Lekhanont |
title |
Association between the levels of prostaglandin E2 in tears and severity of dry eye |
title_short |
Association between the levels of prostaglandin E2 in tears and severity of dry eye |
title_full |
Association between the levels of prostaglandin E2 in tears and severity of dry eye |
title_fullStr |
Association between the levels of prostaglandin E2 in tears and severity of dry eye |
title_full_unstemmed |
Association between the levels of prostaglandin E2 in tears and severity of dry eye |
title_sort |
association between the levels of prostaglandin e2 in tears and severity of dry eye |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2019-07-01 |
description |
AIM: To investigate the relationship between the levels of prostaglandin E2 (PGE2) in tears and dry eye disease severity based on both clinical symptoms and signs.
METHODS: Tear samples were collected from 36 non-Sjögren syndrome dry eye patients (10 males and 26 females, mean age 50.11±11.17y). All participants completed the Ocular Surface Disease Index (OSDI) questionnaire and underwent a detailed ophthalmic examination including, tear film breakup time (TBUT), ocular surface fluorescein staining, Schirmer I test, and meibomian gland assessment. The level of PGE2 in tears was measured using enzyme-linked immunosorbent assay (ELISA). The independent associations between tear PGE2 levels and other variables including demographics, OSDI scores, TBUT, Schirmer scores, ocular surface staining scores, and stage of meibomian gland dysfunction (MGD) were evaluated using linear regression analysis.
RESULTS: The mean PGE2 level in tears of dry eye patients was 537.85±234.02 pg/mL. The tear PGE2 levels significantly positively correlated with OSDI scores (R=0.608, P<0.001), however, they did not significantly associate with TBUT (R=0.153, P=0.373), Schirmer scores (R=-0.098, P=0.570), ocular surface staining scores (R=0.282, P=0.095), and stage of MGD (R=-0.107, P=0.535). Male sex was significantly negatively correlated with tear PGE2 levels.
CONCLUSION: The levels of PGE2 in tears are positively correlated with dry eye symptoms. However, no significant association was found between tear PGE2 levels and the results of other common dry eye diagnostic tests. |
topic |
dry eye prostaglandin e2 severity tear dry eye tests |
url |
http://www.ijo.cn/en_publish/2019/7/20190712.pdf |
work_keys_str_mv |
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