Constituintes químicos e avaliação do potencial antiinflamatório e antioxidante de extratos das folhas de Chomelia obtusa Cham. & Schltdl. (Rubiaceae) Chemical constituents and anti-inflammatory and antioxidant activities evaluation of the leaves extracts of Chomelia obtusa Cham. & Schltdl. (Rubiaceae)

• Main Authors: Michely Pereira de Barros, Silvana Maria de Oliveira Santin, Willian Ferreira da Costa, Gentil José Vidotti, Maria Helena Sarragiotto, Maria Conceição de Souza, Ciomar Aparecida Bersani-Amado
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2008-01-01
• Series: Química Nova
• Subjects: Chomelia obtusa; Guettardeae; chemical constituents
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800013
• ISSN: 0100-4042; 1678-7064

<abstract language="eng">The phytochemical investigation of Chomelia obtusa leaves led to the isolation of four triterpenes (3-O-&#946;-D-quinovopyranosyl-28-O-&#946;-D-glycopyranosyl quinovic acid, 3-O-&#946;-D-quinovopyranosyl-28-O-&#946;-D-glycopyranosyl cincholic acid, and a mixture of ursolic and oleanolic acids), two flavonoids (3-O-&#946;-D-glycopyranosyl quercetin, 3-O-[&#945;-L-rhamnopyranosyl-(1&#8594;6)-&#946;-D-galactopyranoside] quercetin), besides bornesitol and a mixture of 3,5- and 4,5-O-dicaffeoyl quinic acids. The structures of the isolated compounds were assigned on the basis of spectroscopic data, including two-dimensional NMR methods. The anti-inflammatory and antioxidant activities of the crude methanolic extract and of its fractions were evaluated. This is the first report on the chemical and biological investigation of the Chomelia genus.