Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis
Objective: To investigate the correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis. Methods: A total of 118 female patients who were diagnosed with menopausal osteoporosis in the West China Second University Hospital of Sich...
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doaj-21b2ba92bb7d4cd0b6b01684755d13cc2020-11-25T00:39:34ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-02-0124028386Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosisGuo-Min Liu0Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Pidu District Chengdu Sichuan Province, Chengdu, Sichuan Province, 611730Objective: To investigate the correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis. Methods: A total of 118 female patients who were diagnosed with menopausal osteoporosis in the West China Second University Hospital of Sichuan University between September 2015 and October 2017 were selected as menopausal osteoporosis group, and 100 menopausal women with normal bone density who received medical examination in the West China Second University Hospital of Sichuan University during the same period were selected as normal control group. The contents of sex hormones, adipocytokines and bone metabolism biochemical indexes in peripheral blood were compared between two groups of women, and Pearson test was used to evaluate the correlation between sex hormones and disease severity in women with menopausal osteoporosis. Results: E2 content in the peripheral blood of menopausal osteoporosis group was significantly lower than that of control group whereas FSH and LH contents were not significantly different from those of control group; Resistin and chemerin contents in peripheral blood were higher than those of control group whereas LEP and Visfatin contents were lower than those of control group; OC, NBAP, TRACP and ICTP contents in peripheral blood were significantly higher than those of control group. Pearson test showed that the sex hormone E2 content in women with menopausal osteoporosis was directly correlated with the contents of adipocytokines and bone metabolism biochemical indexes. Conclusion: The sex hormone expression is abnormal in women with menopausal osteoporosis, and the specific abnormal level can objectively reflect the condition of osteoporosis.http://www.hnykdxxb.com/PDF/201802/21.pdf Menopausal osteoporosisSex hormoneAdipocytokineBone metabolism biochemical index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guo-Min Liu |
spellingShingle |
Guo-Min Liu Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis Journal of Hainan Medical University Menopausal osteoporosis Sex hormone Adipocytokine Bone metabolism biochemical index |
author_facet |
Guo-Min Liu |
author_sort |
Guo-Min Liu |
title |
Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
title_short |
Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
title_full |
Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
title_fullStr |
Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
title_full_unstemmed |
Correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
title_sort |
correlation of sex hormones with adipocytokines and bone metabolism biochemical indexes in women with menopausal osteoporosis |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-02-01 |
description |
Objective: To investigate the correlation of sex hormones with adipocytokines and bone
metabolism biochemical indexes in women with menopausal osteoporosis. Methods: A total
of 118 female patients who were diagnosed with menopausal osteoporosis in the West China
Second University Hospital of Sichuan University between September 2015 and October
2017 were selected as menopausal osteoporosis group, and 100 menopausal women with
normal bone density who received medical examination in the West China Second University
Hospital of Sichuan University during the same period were selected as normal control group.
The contents of sex hormones, adipocytokines and bone metabolism biochemical indexes in
peripheral blood were compared between two groups of women, and Pearson test was used to
evaluate the correlation between sex hormones and disease severity in women with menopausal
osteoporosis. Results: E2 content in the peripheral blood of menopausal osteoporosis group
was significantly lower than that of control group whereas FSH and LH contents were not
significantly different from those of control group; Resistin and chemerin contents in peripheral
blood were higher than those of control group whereas LEP and Visfatin contents were lower
than those of control group; OC, NBAP, TRACP and ICTP contents in peripheral blood were
significantly higher than those of control group. Pearson test showed that the sex hormone E2
content in women with menopausal osteoporosis was directly correlated with the contents of
adipocytokines and bone metabolism biochemical indexes. Conclusion: The sex hormone
expression is abnormal in women with menopausal osteoporosis, and the specific abnormal
level can objectively reflect the condition of osteoporosis. |
topic |
Menopausal osteoporosis Sex hormone Adipocytokine Bone metabolism biochemical index |
url |
http://www.hnykdxxb.com/PDF/201802/21.pdf |
work_keys_str_mv |
AT guominliu correlationofsexhormoneswithadipocytokinesandbonemetabolismbiochemicalindexesinwomenwithmenopausalosteoporosis |
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