The Determinants of the Human Milk Metabolome and Its Role in Infant Health
Human milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including me...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-02-01
|
Series: | Metabolites |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-1989/10/2/77 |
id |
doaj-21ba447f0ceb40acbba74aa7b11688b6 |
---|---|
record_format |
Article |
spelling |
doaj-21ba447f0ceb40acbba74aa7b11688b62020-11-24T21:53:48ZengMDPI AGMetabolites2218-19892020-02-011027710.3390/metabo10020077metabo10020077The Determinants of the Human Milk Metabolome and Its Role in Infant HealthAnna Ojo-Okunola0Stefano Cacciatore1Mark P. Nicol2Elloise du Toit3Division of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Observatory, Cape Town 7925, South AfricaDivision of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaDivision of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaHuman milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including metabolites such as the lipids, amino acids, biogenic amines and carbohydrates. These components have diverse roles, including protecting the infant against infections and guiding the development of the infant’s immature immune system. In this review, we provide an in-depth and updated insight into the immune modulatory and anti-infective role of human milk metabolites and their effects on infant health and development. We also review the literature on potential determinants of the human milk metabolome, including maternal infectious diseases such as human immunodeficiency virus and mastitis.https://www.mdpi.com/2218-1989/10/2/77metabolomehuman milkmetabolite profileshuman immunodeficiency virusmastitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit |
spellingShingle |
Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit The Determinants of the Human Milk Metabolome and Its Role in Infant Health Metabolites metabolome human milk metabolite profiles human immunodeficiency virus mastitis |
author_facet |
Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit |
author_sort |
Anna Ojo-Okunola |
title |
The Determinants of the Human Milk Metabolome and Its Role in Infant Health |
title_short |
The Determinants of the Human Milk Metabolome and Its Role in Infant Health |
title_full |
The Determinants of the Human Milk Metabolome and Its Role in Infant Health |
title_fullStr |
The Determinants of the Human Milk Metabolome and Its Role in Infant Health |
title_full_unstemmed |
The Determinants of the Human Milk Metabolome and Its Role in Infant Health |
title_sort |
determinants of the human milk metabolome and its role in infant health |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2020-02-01 |
description |
Human milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including metabolites such as the lipids, amino acids, biogenic amines and carbohydrates. These components have diverse roles, including protecting the infant against infections and guiding the development of the infant’s immature immune system. In this review, we provide an in-depth and updated insight into the immune modulatory and anti-infective role of human milk metabolites and their effects on infant health and development. We also review the literature on potential determinants of the human milk metabolome, including maternal infectious diseases such as human immunodeficiency virus and mastitis. |
topic |
metabolome human milk metabolite profiles human immunodeficiency virus mastitis |
url |
https://www.mdpi.com/2218-1989/10/2/77 |
work_keys_str_mv |
AT annaojookunola thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT stefanocacciatore thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT markpnicol thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT elloisedutoit thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT annaojookunola determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT stefanocacciatore determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT markpnicol determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT elloisedutoit determinantsofthehumanmilkmetabolomeanditsroleininfanthealth |
_version_ |
1725870048363413504 |