The Determinants of the Human Milk Metabolome and Its Role in Infant Health

Human milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including me...

Full description

Bibliographic Details
Main Authors:	Anna Ojo-Okunola, Stefano Cacciatore, Mark P. Nicol, Elloise du Toit
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Metabolites
Subjects:	metabolome human milk metabolite profiles human immunodeficiency virus mastitis
Online Access:	https://www.mdpi.com/2218-1989/10/2/77

id	doaj-21ba447f0ceb40acbba74aa7b11688b6
record_format	Article
spelling	doaj-21ba447f0ceb40acbba74aa7b11688b62020-11-24T21:53:48ZengMDPI AGMetabolites2218-19892020-02-011027710.3390/metabo10020077metabo10020077The Determinants of the Human Milk Metabolome and Its Role in Infant HealthAnna Ojo-Okunola0Stefano Cacciatore1Mark P. Nicol2Elloise du Toit3Division of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Observatory, Cape Town 7925, South AfricaDivision of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaDivision of Medical Microbiology, Department of Pathology, University of Cape Town, Observatory, Cape Town 7925, South AfricaHuman milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including metabolites such as the lipids, amino acids, biogenic amines and carbohydrates. These components have diverse roles, including protecting the infant against infections and guiding the development of the infant’s immature immune system. In this review, we provide an in-depth and updated insight into the immune modulatory and anti-infective role of human milk metabolites and their effects on infant health and development. We also review the literature on potential determinants of the human milk metabolome, including maternal infectious diseases such as human immunodeficiency virus and mastitis.https://www.mdpi.com/2218-1989/10/2/77metabolomehuman milkmetabolite profileshuman immunodeficiency virusmastitis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit
spellingShingle	Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit The Determinants of the Human Milk Metabolome and Its Role in Infant Health Metabolites metabolome human milk metabolite profiles human immunodeficiency virus mastitis
author_facet	Anna Ojo-Okunola Stefano Cacciatore Mark P. Nicol Elloise du Toit
author_sort	Anna Ojo-Okunola
title	The Determinants of the Human Milk Metabolome and Its Role in Infant Health
title_short	The Determinants of the Human Milk Metabolome and Its Role in Infant Health
title_full	The Determinants of the Human Milk Metabolome and Its Role in Infant Health
title_fullStr	The Determinants of the Human Milk Metabolome and Its Role in Infant Health
title_full_unstemmed	The Determinants of the Human Milk Metabolome and Its Role in Infant Health
title_sort	determinants of the human milk metabolome and its role in infant health
publisher	MDPI AG
series	Metabolites
issn	2218-1989
publishDate	2020-02-01
description	Human milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including metabolites such as the lipids, amino acids, biogenic amines and carbohydrates. These components have diverse roles, including protecting the infant against infections and guiding the development of the infant’s immature immune system. In this review, we provide an in-depth and updated insight into the immune modulatory and anti-infective role of human milk metabolites and their effects on infant health and development. We also review the literature on potential determinants of the human milk metabolome, including maternal infectious diseases such as human immunodeficiency virus and mastitis.
topic	metabolome human milk metabolite profiles human immunodeficiency virus mastitis
url	https://www.mdpi.com/2218-1989/10/2/77
work_keys_str_mv	AT annaojookunola thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT stefanocacciatore thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT markpnicol thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT elloisedutoit thedeterminantsofthehumanmilkmetabolomeanditsroleininfanthealth AT annaojookunola determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT stefanocacciatore determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT markpnicol determinantsofthehumanmilkmetabolomeanditsroleininfanthealth AT elloisedutoit determinantsofthehumanmilkmetabolomeanditsroleininfanthealth
_version_	1725870048363413504

The Determinants of the Human Milk Metabolome and Its Role in Infant Health

Similar Items