The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts
Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar...
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Mashhad University of Medical Sciences
2018-06-01
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doaj-21bf5355ba7f41bc9bb25b44feb409fa2020-11-24T22:16:31ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492018-06-018433834910.22038/ajp.2018.1031510315The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat heartsHassan Esmaeili0Zahra Hafezimoghadam1Mansour Esmailidehaj2Mohammad Ebrahim Rezvani3Zeynab Hafizibarjin4Department of heart, School of Medicine, Gorgan University of Medical Sciences, Gorgan, IranDepartment of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of physiology, school of medicine, Yazd university of medical sciencesDepartment of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IranObjective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) carvedilol group. In the control group, hearts were only subjected to 30-min global ischemia followed by 120-min reperfusion. Hearts in other groups were perfused with vehicle (Tween 0.1%), AEO (0.125, 0.25 or 0.50 µL/g heart) or carvedilol (10 µM) for 5 min immediately before the induction of ischemia. Results: Compared to the control group, myocardial dysfunction was significantly more severe only in group 5 in which a significant increase in left ventricular end diastolic pressure and a significant decrease in left ventricular developed pressure and ±dp/dt. Also, the activities of lactate dehydrogenase and creatine kinase as the markers of myocardial injury were significantly higher only in group 5 compared to control group. The size of infarct and the incidence of irreversible fibrillation did not show any significant differences between the control group and groups 3-5. Conclusion: These results showed that perfusion of isolated rat hearts with AEO 0.5 µL/g heart, but not at lower concentrations, might worsen myocardial ischemic-reperfusion injury.http://ajp.mums.ac.ir/article_10315_0fc7bfdac51091eb2019d7e2c02f28bf.pdfAsafoetidaHeartEssential oilIschemic-reperfusion injury |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hassan Esmaeili Zahra Hafezimoghadam Mansour Esmailidehaj Mohammad Ebrahim Rezvani Zeynab Hafizibarjin |
spellingShingle |
Hassan Esmaeili Zahra Hafezimoghadam Mansour Esmailidehaj Mohammad Ebrahim Rezvani Zeynab Hafizibarjin The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts Avicenna Journal of Phytomedicine Asafoetida Heart Essential oil Ischemic-reperfusion injury |
author_facet |
Hassan Esmaeili Zahra Hafezimoghadam Mansour Esmailidehaj Mohammad Ebrahim Rezvani Zeynab Hafizibarjin |
author_sort |
Hassan Esmaeili |
title |
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
title_short |
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
title_full |
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
title_fullStr |
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
title_full_unstemmed |
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
title_sort |
effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts |
publisher |
Mashhad University of Medical Sciences |
series |
Avicenna Journal of Phytomedicine |
issn |
2228-7930 2228-7949 |
publishDate |
2018-06-01 |
description |
Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) carvedilol group. In the control group, hearts were only subjected to 30-min global ischemia followed by 120-min reperfusion. Hearts in other groups were perfused with vehicle (Tween 0.1%), AEO (0.125, 0.25 or 0.50 µL/g heart) or carvedilol (10 µM) for 5 min immediately before the induction of ischemia. Results: Compared to the control group, myocardial dysfunction was significantly more severe only in group 5 in which a significant increase in left ventricular end diastolic pressure and a significant decrease in left ventricular developed pressure and ±dp/dt. Also, the activities of lactate dehydrogenase and creatine kinase as the markers of myocardial injury were significantly higher only in group 5 compared to control group. The size of infarct and the incidence of irreversible fibrillation did not show any significant differences between the control group and groups 3-5. Conclusion: These results showed that perfusion of isolated rat hearts with AEO 0.5 µL/g heart, but not at lower concentrations, might worsen myocardial ischemic-reperfusion injury. |
topic |
Asafoetida Heart Essential oil Ischemic-reperfusion injury |
url |
http://ajp.mums.ac.ir/article_10315_0fc7bfdac51091eb2019d7e2c02f28bf.pdf |
work_keys_str_mv |
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