A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer
Objective: To compare the efficacy and safety of hyperthermic intravesical chemotherapy (HIVEC) and intravesical chemotherapy (IVEC) in patients with intermediate and high risk nonmuscle-invasive bladder cancer (NMIBC) after transurethral resection. Methods: We included 560 patients diagnosed with p...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
China Anti-Cancer Association
2021-02-01
|
Series: | Cancer Biology & Medicine |
Subjects: | |
Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1789 |
id |
doaj-21bfce43c9a04c2281c9467392220f97 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui |
spellingShingle |
Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer Cancer Biology & Medicine nonmuscle-invasive bladder cancer intravesical chemotherapy hyperthermia chemohyperthermia retrospective study |
author_facet |
Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui |
author_sort |
Qiang Ruan |
title |
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
title_short |
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
title_full |
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
title_fullStr |
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
title_full_unstemmed |
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
title_sort |
multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer |
publisher |
China Anti-Cancer Association |
series |
Cancer Biology & Medicine |
issn |
2095-3941 |
publishDate |
2021-02-01 |
description |
Objective: To compare the efficacy and safety of hyperthermic intravesical chemotherapy (HIVEC) and intravesical chemotherapy (IVEC) in patients with intermediate and high risk nonmuscle-invasive bladder cancer (NMIBC) after transurethral resection. Methods: We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers. We matched 364 intermediate or high risk cases and divided them into 2 groups: the HIVEC+IVEC group [chemohyperthermia (CHT) composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia] and the IVEC group (intravesical instillation without hyperthermia). The data were recorded in the database. The primary endpoint was 2-year recurrence-free survival (RFS) in all NMIBC patients (n = 364), whereas the secondary endpoints were the assessment of radical cystectomy (RC) and 5-year overall survival (OS). Results: There was a significant difference in the 2-year RFS between the two groups in all patients (n = 364; HIVEC+IVEC: 82.42% vs. IVEC: 74.18%, P = 0.038). Compared with the IVEC group, the HIVEC+IVEC group had a lower incidence of RC (P = 0.0274). However, the 5-year OS was the same between the 2 groups (P = 0.1434). Adverse events (AEs) occurred in 32.7% of all patients, but none of the events was serious (grades 3–4). No difference in the incidence or severity of AEs between each treatment modality was observed. Conclusions: This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients. Both treatments were well-tolerated in a similar manner. |
topic |
nonmuscle-invasive bladder cancer intravesical chemotherapy hyperthermia chemohyperthermia retrospective study |
url |
http://www.cancerbiomed.org/index.php/cocr/article/view/1789 |
work_keys_str_mv |
AT qiangruan amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT degangding amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT binwang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT chaohonghe amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT xuequnren amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT zhenhuafeng amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT zhigangpang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jinwang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT xiangliangzhang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT hongshengtang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jiahongwang amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT qingjunhe amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT ziyinglei amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT quanxingliao amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jialiluo amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT shuzhongcui amultiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT qiangruan multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT degangding multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT binwang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT chaohonghe multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT xuequnren multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT zhenhuafeng multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT zhigangpang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jinwang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT xiangliangzhang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT hongshengtang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jiahongwang multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT qingjunhe multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT ziyinglei multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT quanxingliao multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT jialiluo multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer AT shuzhongcui multiinstitutionalretrospectivestudyofhyperthermicplusintravesicalchemotherapyversusintravesicalchemotherapytreatmentaloneinintermediateandhighrisknonmuscleinvasivebladdercancer |
_version_ |
1724268819165216768 |
spelling |
doaj-21bfce43c9a04c2281c9467392220f972021-02-15T14:05:15ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412021-02-0118130831710.20892/j.issn.2095-3941.2020.0125A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancerQiang Ruan0Degang Ding1Bin Wang2Chaohong He3Xuequn Ren4Zhenhua Feng5Zhigang Pang6Jin Wang7Xiangliang Zhang8Hongsheng Tang9Jiahong Wang10Qingjun He11Ziying Lei12Quanxing Liao13Jiali Luo14Shuzhong Cui15Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Urinary Surgery, Henan Provincial People’s Hospital, Zhengzhou 450003, ChinaDepartment of Urinary Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Urinary Surgery, Henan Cancer Hospital, Zhengzhou 450008, ChinaDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Urinary Surgery, Gaozhou People’s Hospital, Maoming 525200, ChinaDepartment of General Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, ChinaObjective: To compare the efficacy and safety of hyperthermic intravesical chemotherapy (HIVEC) and intravesical chemotherapy (IVEC) in patients with intermediate and high risk nonmuscle-invasive bladder cancer (NMIBC) after transurethral resection. Methods: We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers. We matched 364 intermediate or high risk cases and divided them into 2 groups: the HIVEC+IVEC group [chemohyperthermia (CHT) composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia] and the IVEC group (intravesical instillation without hyperthermia). The data were recorded in the database. The primary endpoint was 2-year recurrence-free survival (RFS) in all NMIBC patients (n = 364), whereas the secondary endpoints were the assessment of radical cystectomy (RC) and 5-year overall survival (OS). Results: There was a significant difference in the 2-year RFS between the two groups in all patients (n = 364; HIVEC+IVEC: 82.42% vs. IVEC: 74.18%, P = 0.038). Compared with the IVEC group, the HIVEC+IVEC group had a lower incidence of RC (P = 0.0274). However, the 5-year OS was the same between the 2 groups (P = 0.1434). Adverse events (AEs) occurred in 32.7% of all patients, but none of the events was serious (grades 3–4). No difference in the incidence or severity of AEs between each treatment modality was observed. Conclusions: This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients. Both treatments were well-tolerated in a similar manner.http://www.cancerbiomed.org/index.php/cocr/article/view/1789nonmuscle-invasive bladder cancerintravesical chemotherapyhyperthermiachemohyperthermiaretrospective study |