A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

Although genetic factors are considered a main etiology of epilepsy, the causes of genetic epilepsy in the majority of epilepsy patients remain unknown. Kinesin family member 1A (KIF1A), a neuron-specific motor protein that moves along with microtubules, is responsible for the transport of membranou...

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Bibliographic Details
Main Authors: Yi Guo, Yuanyuan Chen, Min Yang, Xin Xu, Zijun Lin, Junhong Ma, Hongnian Chen, Yida Hu, Yuanlin Ma, Xuefeng Wang, Xin Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
KIF1A
epilepsy
synaptic plasticity
dendritic spine
epileptogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00061/full

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