Evaluation of rheological and mucoadhesive properties of selected nasal spray preparations with mometasone furoate
Intranasal preparations with mometasone furoate are recognised to be highly efficient and safe in both adults and children. Commercially available nasal sprays are characterised by thixotropic and mucoadhesive properties – factors ensuring effortless drug dosing followed by prolonged retention tim...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Medical Communications Sp. z o.o.
2017-06-01
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Series: | Pediatria i Medycyna Rodzinna |
Subjects: | |
Online Access: | http://www.pimr.pl/index.php/issues/2017-vol-13-no-2/evaluation-of-rheological-and-mucoadhesive-properties-of-selected-nasal-spray-preparations-with-mometasone-furoate?aid=1071 |
Summary: | Intranasal preparations with mometasone furoate are recognised to be highly efficient and safe in both adults and children.
Commercially available nasal sprays are characterised by thixotropic and mucoadhesive properties – factors ensuring
effortless drug dosing followed by prolonged retention time in the nasal cavity. Thixotropy and mucoadhesiveness is not
a constant value and it is determined by the presence of proper excipients in the preparation’s composition. The aim of the
study was to compare rheological and mechanical properties of selected nasal spray formulations with mometasone furoate.
In addition, these preparations were investigated for their ex vivo mucoadhesive behaviour to the porcine nasal mucosa.
These experiments revealed differences in viscosity and thixotropic properties between nasal sprays depending on the
measurement temperature. All analysed preparations possessed mucoadhesive properties in ex vivo conditions.
Viscosity and mechanical measurements of the analysed preparations were found to be correlated with the mucoadhesive
behaviour in contact with porcine nasal mucosa. An important role of the agitation process on the formulations’ hardness
and consistency was also demonstrated. |
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ISSN: | 1734-1531 2451-0742 |