Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome

Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) is a neurodevelopmental disease in children that is mainly caused by mutations in the MeCP2 gene, which codes for a transcriptional regulator. The expression of insulin-like growth factor-1 (IGF-1) is reduced in RTT patients and animal models, and IGF-1 treatment is a promising t...

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Bibliographic Details
Main Authors: Zhe-Feng Yuan, Shan-Shan Mao, Jue Shen, Li-Hua Jiang, Lu Xu, Jia-Lu Xu, Feng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Neuroscience
Subjects:
Rett syndrome
IGF-1
MeCP2 mutant mice
FXYD1
neurodevelopmental disorders
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00020/full

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