Marburg virus disease: A summary for clinicians
Objectives: This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for...
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2020-10-01
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doaj-21d2a160ea2344d5944a34b1bf2ef0852020-11-25T03:57:33ZengElsevierInternational Journal of Infectious Diseases1201-97122020-10-0199233242Marburg virus disease: A summary for cliniciansMark G. Kortepeter0Kerry Dierberg1Erica S. Shenoy2Theodore J. Cieslak3University of Nebraska Medical Center, Omaha, NE, USA; Corresponding author at: 98435 Nebraska Medical Center Omaha, NE 68198-4395.Bellevue Hospital Center, New York, NY, USAMassachusetts General Hospital, Boston, MA, USAUniversity of Nebraska Medical Center, Omaha, NE, USAObjectives: This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation. Methods: A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods that were used is summarized in a companion methods paper. Results: The study identified six treatments and four vaccine platforms that have demonstrated, through their efficacy in NHPs, potential benefit for treating or preventing infection in humans. Conclusion: Succinct summaries of Marburg countermeasures are provided to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. Links to other authoritative sources of information are also provided.http://www.sciencedirect.com/science/article/pii/S1201971220305865Marburg virusFilovirusEbola virusAntiviral therapyAntiviral countermeasureVaccine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mark G. Kortepeter Kerry Dierberg Erica S. Shenoy Theodore J. Cieslak |
spellingShingle |
Mark G. Kortepeter Kerry Dierberg Erica S. Shenoy Theodore J. Cieslak Marburg virus disease: A summary for clinicians International Journal of Infectious Diseases Marburg virus Filovirus Ebola virus Antiviral therapy Antiviral countermeasure Vaccine |
author_facet |
Mark G. Kortepeter Kerry Dierberg Erica S. Shenoy Theodore J. Cieslak |
author_sort |
Mark G. Kortepeter |
title |
Marburg virus disease: A summary for clinicians |
title_short |
Marburg virus disease: A summary for clinicians |
title_full |
Marburg virus disease: A summary for clinicians |
title_fullStr |
Marburg virus disease: A summary for clinicians |
title_full_unstemmed |
Marburg virus disease: A summary for clinicians |
title_sort |
marburg virus disease: a summary for clinicians |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2020-10-01 |
description |
Objectives: This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation. Methods: A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods that were used is summarized in a companion methods paper. Results: The study identified six treatments and four vaccine platforms that have demonstrated, through their efficacy in NHPs, potential benefit for treating or preventing infection in humans. Conclusion: Succinct summaries of Marburg countermeasures are provided to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. Links to other authoritative sources of information are also provided. |
topic |
Marburg virus Filovirus Ebola virus Antiviral therapy Antiviral countermeasure Vaccine |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220305865 |
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