Marburg virus disease: A summary for clinicians

• Main Authors: Mark G. Kortepeter, Kerry Dierberg, Erica S. Shenoy, Theodore J. Cieslak
• Format: Article
• Language: English
• Published: Elsevier 2020-10-01
• Series: International Journal of Infectious Diseases
• Subjects: Marburg virus; Filovirus; Ebola virus; Antiviral therapy; Antiviral countermeasure; Vaccine
• Online Access: http://www.sciencedirect.com/science/article/pii/S1201971220305865

Objectives: This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation. Methods: A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods that were used is summarized in a companion methods paper. Results: The study identified six treatments and four vaccine platforms that have demonstrated, through their efficacy in NHPs, potential benefit for treating or preventing infection in humans. Conclusion: Succinct summaries of Marburg countermeasures are provided to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. Links to other authoritative sources of information are also provided.