Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phen...

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Main Authors: Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10664
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spelling doaj-21df8f4c58ab49ee8a88f25945d57d732021-05-11T11:08:42ZengNature Publishing GroupNature Communications2041-17232016-02-017111610.1038/ncomms10664Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migrationHadir Marei0Alejandro Carpy1Anna Woroniuk2Claire Vennin3Gavin White4Paul Timpson5Boris Macek6Angeliki Malliri7Cell Signalling Group, Cancer Research UK Manchester Institute, The University of ManchesterProteome Center Tuebingen, Interfaculty Institute for Cell Biology, University of TuebingenCell Signalling Group, Cancer Research UK Manchester Institute, The University of ManchesterInvasion and Metastasis Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Faculty of Medicine, St Vincent’s Clinical School, University of New South WalesCell Signalling Group, Cancer Research UK Manchester Institute, The University of ManchesterInvasion and Metastasis Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Faculty of Medicine, St Vincent’s Clinical School, University of New South WalesProteome Center Tuebingen, Interfaculty Institute for Cell Biology, University of TuebingenCell Signalling Group, Cancer Research UK Manchester Institute, The University of ManchesterThe small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phenotype.https://doi.org/10.1038/ncomms10664
collection DOAJ
language English
format Article
sources DOAJ
author Hadir Marei
Alejandro Carpy
Anna Woroniuk
Claire Vennin
Gavin White
Paul Timpson
Boris Macek
Angeliki Malliri
spellingShingle Hadir Marei
Alejandro Carpy
Anna Woroniuk
Claire Vennin
Gavin White
Paul Timpson
Boris Macek
Angeliki Malliri
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
Nature Communications
author_facet Hadir Marei
Alejandro Carpy
Anna Woroniuk
Claire Vennin
Gavin White
Paul Timpson
Boris Macek
Angeliki Malliri
author_sort Hadir Marei
title Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_short Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_full Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_fullStr Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_full_unstemmed Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_sort differential rac1 signalling by guanine nucleotide exchange factors implicates flii in regulating rac1-driven cell migration
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phenotype.
url https://doi.org/10.1038/ncomms10664
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