BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

Tumor suppressor p53 is the most frequently mutated gene in tumors. Many mutant p53 (mutp53) proteins promote tumorigenesis through the gain-of-function (GOF) mechanism. Mutp53 proteins often accumulate to high levels in tumors, which is critical for mutp53 GOF. Its underlying mechanism is poorly un...

Full description

Bibliographic Details
Main Authors: Xuetian Yue, Yuhan Zhao, Juan Liu, Cen Zhang, Haiyang Yu, Jiabei Wang, Tongsen Zheng, Lianxin Liu, Jun Li, Zhaohui Feng, Wenwei Hu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
mutant p53
BAG2
tumorigenesis
Online Access:https://elifesciences.org/articles/08401

Similar Items

Similar Items