Mitochondrial oxidative damage and apoptosis induced by high glucose through Rho kinase signal pathway in renal tubular epithelial cells

Mitochondrial oxidative damage and apoptosis induced by high glucose through Rho kinase signal pathway in renal tubular epithelial cells

Objective: To investigate the role of oxidative stress in human renal tubular epithelial cells (HK-2) induced by high glucose and the underlying signal pathway in vitro. Methods: MYPT1, pro-caspase-3, PGC-1α, and Drp1 protein expressions were measured by Western blot. MnSOD2, Drp1 and PGC-1α mRNA ex...

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Bibliographic Details
Main Authors: Wen-Ning Li, Hui Han, Zi-Yang Jing, Xiao-Hong Yang, Yin Zhang, Jia-Li Wei
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
diabetic nephropathy
mitochondrial oxidative stress
rho kinase signal pathway
tubular epithelial cell
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=6;spage=399;epage=404;aulast=Li

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