Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness
Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root...
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Yeungnam University College of Medicine
2021-07-01
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doaj-21fcec69f471455a86c6ab4a21a1cd382021-06-22T00:18:48ZengYeungnam University College of MedicineYeungnam University Journal of Medicine2384-02932021-07-0138325826310.12701/yujm.2021.009832639Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weaknessKyoung Tae Kim0Se Il Kim1Young Rok Do2Hye Ra Jung3Jang Hyuk Cho4 Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea Department of Pathology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaNeurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. NL often occurs in malignant B-cell non-Hodgkin lymphomas. Notwithstanding its aggressiveness or intractability, NL should be discriminated from other neurologic complications of lymphoma. Herein, we present a case of primary NL as the initial presentation of diffuse large B-cell lymphoma (DLBCL) of the sciatic nerve. The patient presented with weakness and pain in his left leg but had no obvious lesion explaining the neurologic deficit on initial lumbosacral and knee magnetic resonance imaging (MRI). NL of the left sciatic nerve at the greater sciatic foramen was diagnosed based on subsequent hip MRI, electrodiagnostic test, positron emission tomography/computed tomography, and nerve biopsy findings. Leg weakness slightly improved after chemotherapy and radiotherapy. We report a case wherein NL, a rare cause of leg weakness, manifested as the initial presentation of primary DLBCL involving the sciatic nerve at the greater sciatic foramen.http://www.e-yujm.org/upload/pdf/yujm-2021-00983.pdfdiffuse large b-cell lymphomaneurolymphomatosisneuropathysciatic nerve |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyoung Tae Kim Se Il Kim Young Rok Do Hye Ra Jung Jang Hyuk Cho |
spellingShingle |
Kyoung Tae Kim Se Il Kim Young Rok Do Hye Ra Jung Jang Hyuk Cho Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness Yeungnam University Journal of Medicine diffuse large b-cell lymphoma neurolymphomatosis neuropathy sciatic nerve |
author_facet |
Kyoung Tae Kim Se Il Kim Young Rok Do Hye Ra Jung Jang Hyuk Cho |
author_sort |
Kyoung Tae Kim |
title |
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness |
title_short |
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness |
title_full |
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness |
title_fullStr |
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness |
title_full_unstemmed |
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness |
title_sort |
sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large b-cell lymphoma: a rare cause of leg weakness |
publisher |
Yeungnam University College of Medicine |
series |
Yeungnam University Journal of Medicine |
issn |
2384-0293 |
publishDate |
2021-07-01 |
description |
Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. NL often occurs in malignant B-cell non-Hodgkin lymphomas. Notwithstanding its aggressiveness or intractability, NL should be discriminated from other neurologic complications of lymphoma. Herein, we present a case of primary NL as the initial presentation of diffuse large B-cell lymphoma (DLBCL) of the sciatic nerve. The patient presented with weakness and pain in his left leg but had no obvious lesion explaining the neurologic deficit on initial lumbosacral and knee magnetic resonance imaging (MRI). NL of the left sciatic nerve at the greater sciatic foramen was diagnosed based on subsequent hip MRI, electrodiagnostic test, positron emission tomography/computed tomography, and nerve biopsy findings. Leg weakness slightly improved after chemotherapy and radiotherapy. We report a case wherein NL, a rare cause of leg weakness, manifested as the initial presentation of primary DLBCL involving the sciatic nerve at the greater sciatic foramen. |
topic |
diffuse large b-cell lymphoma neurolymphomatosis neuropathy sciatic nerve |
url |
http://www.e-yujm.org/upload/pdf/yujm-2021-00983.pdf |
work_keys_str_mv |
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