Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis
Hippocampal somatostatin (SST)-neprilysin (NEP) system functions as a defense system against neurotoxic soluble amyloid-β oligomers associated with onset of Alzheimer’s disease. However, it remains unknown whether royal jelly (RJ) could impact the defense system. In this study using primary cultures...
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doaj-21feb888195f4849b5a9c6c1cf91a59b2021-04-30T07:14:51ZengElsevierJournal of Functional Foods1756-46462018-12-01512838Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesisIchiro Kawahata0Huinan Xu1Michiyo Takahashi2Kiyoshi Murata3Wanying Han4Yoshihisa Yamaguchi5Akira Fujii6Kikuji Yamaguchi7Tohru Yamakuni8Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanJRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, JapanJRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanTohoku Fukushi University, Sendai 981-8523, Japan; Japan Royal Jelly Co. Ltd, Tokyo 163-0636, JapanJRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, Japan; Nihon University, Tokyo 102-8275, JapanJRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, Japan; Tohoku Fukushi University, Sendai 981-8523, Japan; College of Plant Protection, Yunnan Agricultural University, Kunming, Yunnan 650201, China; Corresponding authors at: JRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, Japan (K. Yamaguchi). Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan (T. Yamakuni).Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Corresponding authors at: JRJ Institute of Apimedical Science, Japan Royal Jelly Co. Ltd, Tokyo 103-0025, Japan (K. Yamaguchi). Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan (T. Yamakuni).Hippocampal somatostatin (SST)-neprilysin (NEP) system functions as a defense system against neurotoxic soluble amyloid-β oligomers associated with onset of Alzheimer’s disease. However, it remains unknown whether royal jelly (RJ) could impact the defense system. In this study using primary cultures of hippocampal neurons, including SST-positive and NEP-positive neuronal subsets, we evaluated the ability of DMSO-soluble fraction of RJ (DRJ) to enhance SST and NEP genes expression. The DRJ potently facilitated CRE-mediated transcription, and raised SST-immunoreactivity in an SST-positive neuronal subset, where elevated phospho-CREB immunoreactivity was simultaneously observed. Chromatin immunoprecipitation-qPCR assays uncovered that the DRJ mechanistically facilitated CREB-binding to a CRE present at the promoter region of SST. Moreover, in a distinct NEP-positive neuronal subset, the DRJ led to elevation of NEP immunoreactivity, which was abolished by cyclosomatostatin, a non-selective SST receptors antagonist. Collectively, these findings provide the first evidence that the RJ possesses potential to activate the hippocampal SST-NEP system.http://www.sciencedirect.com/science/article/pii/S1756464618305255Royal jellyCREBCRE-mediated transcriptionSomatostatinNeprilysinHippocampal neurons |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ichiro Kawahata Huinan Xu Michiyo Takahashi Kiyoshi Murata Wanying Han Yoshihisa Yamaguchi Akira Fujii Kikuji Yamaguchi Tohru Yamakuni |
spellingShingle |
Ichiro Kawahata Huinan Xu Michiyo Takahashi Kiyoshi Murata Wanying Han Yoshihisa Yamaguchi Akira Fujii Kikuji Yamaguchi Tohru Yamakuni Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis Journal of Functional Foods Royal jelly CREB CRE-mediated transcription Somatostatin Neprilysin Hippocampal neurons |
author_facet |
Ichiro Kawahata Huinan Xu Michiyo Takahashi Kiyoshi Murata Wanying Han Yoshihisa Yamaguchi Akira Fujii Kikuji Yamaguchi Tohru Yamakuni |
author_sort |
Ichiro Kawahata |
title |
Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis |
title_short |
Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis |
title_full |
Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis |
title_fullStr |
Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis |
title_full_unstemmed |
Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis |
title_sort |
royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in alzheimer’s disease pathogenesis |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2018-12-01 |
description |
Hippocampal somatostatin (SST)-neprilysin (NEP) system functions as a defense system against neurotoxic soluble amyloid-β oligomers associated with onset of Alzheimer’s disease. However, it remains unknown whether royal jelly (RJ) could impact the defense system. In this study using primary cultures of hippocampal neurons, including SST-positive and NEP-positive neuronal subsets, we evaluated the ability of DMSO-soluble fraction of RJ (DRJ) to enhance SST and NEP genes expression. The DRJ potently facilitated CRE-mediated transcription, and raised SST-immunoreactivity in an SST-positive neuronal subset, where elevated phospho-CREB immunoreactivity was simultaneously observed. Chromatin immunoprecipitation-qPCR assays uncovered that the DRJ mechanistically facilitated CREB-binding to a CRE present at the promoter region of SST. Moreover, in a distinct NEP-positive neuronal subset, the DRJ led to elevation of NEP immunoreactivity, which was abolished by cyclosomatostatin, a non-selective SST receptors antagonist. Collectively, these findings provide the first evidence that the RJ possesses potential to activate the hippocampal SST-NEP system. |
topic |
Royal jelly CREB CRE-mediated transcription Somatostatin Neprilysin Hippocampal neurons |
url |
http://www.sciencedirect.com/science/article/pii/S1756464618305255 |
work_keys_str_mv |
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