A systematic approach to the development of a safe live attenuated Zika vaccine
A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.
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Nature Publishing Group
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03337-2 |
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doaj-2200a4c3d0464f52b6e961470788a10a2021-05-11T10:20:52ZengNature Publishing GroupNature Communications2041-17232018-03-019111310.1038/s41467-018-03337-2A systematic approach to the development of a safe live attenuated Zika vaccineSwee Sen Kwek0Satoru Watanabe1Kuan Rong Chan2Eugenia Z. Ong3Hwee Cheng Tan4Wy Ching Ng5Mien T. X. Nguyen6Esther S. Gan7Summer L. Zhang8Kitti W. K. Chan9Jun Hao Tan10October M. Sessions11Menchie Manuel12Julien Pompon13Camillus Chua14Sharifah Hazirah15Karl Tryggvason16Subhash G. Vasudevan17Eng Eong Ooi18Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolSingHealth Translational Immunology and Inflammation Centre, SingHealthSingHealth Translational Immunology and Inflammation Centre, SingHealthProgramme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical SchoolA Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.https://doi.org/10.1038/s41467-018-03337-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Swee Sen Kwek Satoru Watanabe Kuan Rong Chan Eugenia Z. Ong Hwee Cheng Tan Wy Ching Ng Mien T. X. Nguyen Esther S. Gan Summer L. Zhang Kitti W. K. Chan Jun Hao Tan October M. Sessions Menchie Manuel Julien Pompon Camillus Chua Sharifah Hazirah Karl Tryggvason Subhash G. Vasudevan Eng Eong Ooi |
| spellingShingle |
Swee Sen Kwek Satoru Watanabe Kuan Rong Chan Eugenia Z. Ong Hwee Cheng Tan Wy Ching Ng Mien T. X. Nguyen Esther S. Gan Summer L. Zhang Kitti W. K. Chan Jun Hao Tan October M. Sessions Menchie Manuel Julien Pompon Camillus Chua Sharifah Hazirah Karl Tryggvason Subhash G. Vasudevan Eng Eong Ooi A systematic approach to the development of a safe live attenuated Zika vaccine Nature Communications |
| author_facet |
Swee Sen Kwek Satoru Watanabe Kuan Rong Chan Eugenia Z. Ong Hwee Cheng Tan Wy Ching Ng Mien T. X. Nguyen Esther S. Gan Summer L. Zhang Kitti W. K. Chan Jun Hao Tan October M. Sessions Menchie Manuel Julien Pompon Camillus Chua Sharifah Hazirah Karl Tryggvason Subhash G. Vasudevan Eng Eong Ooi |
| author_sort |
Swee Sen Kwek |
| title |
A systematic approach to the development of a safe live attenuated Zika vaccine |
| title_short |
A systematic approach to the development of a safe live attenuated Zika vaccine |
| title_full |
A systematic approach to the development of a safe live attenuated Zika vaccine |
| title_fullStr |
A systematic approach to the development of a safe live attenuated Zika vaccine |
| title_full_unstemmed |
A systematic approach to the development of a safe live attenuated Zika vaccine |
| title_sort |
systematic approach to the development of a safe live attenuated zika vaccine |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-03-01 |
| description |
A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models. |
| url |
https://doi.org/10.1038/s41467-018-03337-2 |
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