Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease

Keiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medic...

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Main Authors: Hirai K, Morino J, Minato S, Kaneko S, Yanai K, Mutsuyoshi Y, Ishii H, Matsuyama M, Kitano T, Aomatsu A, Miyazawa H, Ito K, Ueda Y, Ookawara S, Morishita Y
Format: Article
Language:English
Published: Dove Medical Press 2020-10-01
Series:Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Subjects:
Online Access:https://www.dovepress.com/factors-associated-with-the-change-in-carotid-maximum-intima-media-thi-peer-reviewed-article-DMSO
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spelling doaj-2200f637e21a4cc9a91e45b781314aea2020-11-25T01:53:33ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity : Targets and Therapy1178-70072020-10-01Volume 133637364357986Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney DiseaseHirai KMorino JMinato SKaneko SYanai KMutsuyoshi YIshii HMatsuyama MKitano TAomatsu AMiyazawa HIto KUeda YOokawara SMorishita YKeiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama-ken 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpPurpose: The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients.Methods: In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses.Results: Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT.Conclusion: Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.Keywords: atherosclerosis, carotid maximum intima-media thickness, chronic kidney diseasehttps://www.dovepress.com/factors-associated-with-the-change-in-carotid-maximum-intima-media-thi-peer-reviewed-article-DMSOatherosclerosiscarotid maximum intima-media thicknesschronic kidney disease
collection DOAJ
language English
format Article
sources DOAJ
author Hirai K
Morino J
Minato S
Kaneko S
Yanai K
Mutsuyoshi Y
Ishii H
Matsuyama M
Kitano T
Aomatsu A
Miyazawa H
Ito K
Ueda Y
Ookawara S
Morishita Y
spellingShingle Hirai K
Morino J
Minato S
Kaneko S
Yanai K
Mutsuyoshi Y
Ishii H
Matsuyama M
Kitano T
Aomatsu A
Miyazawa H
Ito K
Ueda Y
Ookawara S
Morishita Y
Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
atherosclerosis
carotid maximum intima-media thickness
chronic kidney disease
author_facet Hirai K
Morino J
Minato S
Kaneko S
Yanai K
Mutsuyoshi Y
Ishii H
Matsuyama M
Kitano T
Aomatsu A
Miyazawa H
Ito K
Ueda Y
Ookawara S
Morishita Y
author_sort Hirai K
title Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
title_short Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
title_full Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
title_fullStr Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
title_full_unstemmed Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
title_sort factors associated with the change in carotid maximum intima-media thickness in patients with moderate-to-advanced stage chronic kidney disease
publisher Dove Medical Press
series Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
issn 1178-7007
publishDate 2020-10-01
description Keiji Hirai, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, JapanCorrespondence: Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama-ken 330-8503, JapanTel +81-48-647-2111Fax +81-48-647-6831Email keijihirai@kfy.biglobe.ne.jpPurpose: The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients.Methods: In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses.Results: Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT.Conclusion: Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.Keywords: atherosclerosis, carotid maximum intima-media thickness, chronic kidney disease
topic atherosclerosis
carotid maximum intima-media thickness
chronic kidney disease
url https://www.dovepress.com/factors-associated-with-the-change-in-carotid-maximum-intima-media-thi-peer-reviewed-article-DMSO
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