Hericium erinaceus enhances neurotrophic factors and prevents cochlear cell apoptosis in senescence accelerated mice

• Main Authors: Juen-Haur Hwang, Chin-Chu Chen, Li-Ya Lee, Hung-Te Chiang, Ming-Fu Wang, Yin-Ching Chan
• Format: Article
• Language: English
• Published: Elsevier 2020-03-01
• Series: Journal of Functional Foods
• Subjects: Age-related hearing impairment; Hericium erinaceus; Neurotrophic factors; Caspase-independent apoptosis; Cochlea; SAMP8 mice
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464620300566

This study aimed to investigate the effects of Hericium erinaceus (HE) on auditory function. Twenty-four 9-month-old male senescence-accelerated prone 8 (SAMP8) mice were randomly and equally assigned to the control group (group A) and two groups supplemented with 215.25 (group B) or 430.5 mg/kg BW of HE (group C) for 12 weeks. Compared with group A, group C had significantly smaller threshold shifts by auditory brainstem responses at the end of study. HE increased nerve growth factor (NGF) expressions in the spiral ganglion neurons (SGNs) and the temporal lobes, and also prevented outer hair cells (OHCs) loss in the middle turn of cochlea. In addition, group C had significantly lower apoptosis-inducing factor and poly (ADP-ribose) polymerase-1 expressions in the middle turn of cochlea, brainstem and temporal lobes. In conclusions, HE could prevent hearing degeneration possibly by increasing neurotrophic expression, preventing OHCs loss, and reducing the caspase-independent apoptosis signalings.