Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.
The SLC30A8 gene codes for a pancreatic beta-cell-expressed zinc transporter, ZnT8. A polymorphism in the SLC30A8 gene is associated with susceptibility to type 2 diabetes, although the molecular mechanism through which this phenotype is manifest is incompletely understood. Such polymorphisms may ex...
Main Authors: | Yi Fu, Wei Tian, Emily B Pratt, Lisa B Dirling, Show-Ling Shyng, Charles K Meshul, David M Cohen |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-05-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2682581?pdf=render |
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