Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature
BackgroundHistological grading typically reflects the biological behavior of solid tumors, thus providing valuable prognostic information. This is also expected in hepatocellular carcinoma (HCC), although limited access to biopsy samples and a lack of standardization might hinder its full predictive...
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doaj-22148ead840148bc96aa789b5a87a3c82020-11-24T23:28:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2017-11-01410.3389/fmed.2017.00193298206Histological Grading of Hepatocellular Carcinoma—A Systematic Review of LiteratureSebastiao N. Martins-Filho0Sebastiao N. Martins-Filho1Caterina Paiva2Raymundo Soares Azevedo3Venancio Avancini Ferreira Alves4Venancio Avancini Ferreira Alves5Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, BrazilLaboratorio de Patologia do Fígado LIM 14, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, BrazilDepartamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, BrazilDepartamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, BrazilDepartamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, BrazilLaboratorio de Patologia do Fígado LIM 14, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, BrazilBackgroundHistological grading typically reflects the biological behavior of solid tumors, thus providing valuable prognostic information. This is also expected in hepatocellular carcinoma (HCC), although limited access to biopsy samples and a lack of standardization might hinder its full predictive value in this cancer.ObjectivesIn order to better understand the current practices of histological grading in HCC, we examined the latest publications addressing its impact on the outcome of patients following surgical treatment.MethodsWe searched the PubMed (MEDLINE) database under the headings “hepatocellular carcinoma,” “grade OR grading,” and “prognosis.” Qualitative and quantitative assessment of publications was performed according to the reference they used to grade their tumors (e.g., Edmondson–Steiner, World Health Organization).ResultsWe reviewed a total of 216 articles: 114 enclosed adequate information and were included herein. Among these, we found divergences and inaccuracies in the histological grade assessment of this cancer, which might have led to a non-standardized grade distribution, with further impact on data analysis. Nevertheless, in most of them, poor tumor differentiation correlated with worse prognosis, expressed by lower overall and/or disease-free survival.ConclusionWhile histological grading of HCC has an important prognostic role, there is an unsatisfactory heterogeneity on the microscopic assessment of this tumor, urging for a movement toward standardization.http://journal.frontiersin.org/article/10.3389/fmed.2017.00193/fullhepatocellular carcinomahistological gradinggrading systemsEdmondson and Steinerprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sebastiao N. Martins-Filho Sebastiao N. Martins-Filho Caterina Paiva Raymundo Soares Azevedo Venancio Avancini Ferreira Alves Venancio Avancini Ferreira Alves |
spellingShingle |
Sebastiao N. Martins-Filho Sebastiao N. Martins-Filho Caterina Paiva Raymundo Soares Azevedo Venancio Avancini Ferreira Alves Venancio Avancini Ferreira Alves Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature Frontiers in Medicine hepatocellular carcinoma histological grading grading systems Edmondson and Steiner prognosis |
author_facet |
Sebastiao N. Martins-Filho Sebastiao N. Martins-Filho Caterina Paiva Raymundo Soares Azevedo Venancio Avancini Ferreira Alves Venancio Avancini Ferreira Alves |
author_sort |
Sebastiao N. Martins-Filho |
title |
Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature |
title_short |
Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature |
title_full |
Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature |
title_fullStr |
Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature |
title_full_unstemmed |
Histological Grading of Hepatocellular Carcinoma—A Systematic Review of Literature |
title_sort |
histological grading of hepatocellular carcinoma—a systematic review of literature |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2017-11-01 |
description |
BackgroundHistological grading typically reflects the biological behavior of solid tumors, thus providing valuable prognostic information. This is also expected in hepatocellular carcinoma (HCC), although limited access to biopsy samples and a lack of standardization might hinder its full predictive value in this cancer.ObjectivesIn order to better understand the current practices of histological grading in HCC, we examined the latest publications addressing its impact on the outcome of patients following surgical treatment.MethodsWe searched the PubMed (MEDLINE) database under the headings “hepatocellular carcinoma,” “grade OR grading,” and “prognosis.” Qualitative and quantitative assessment of publications was performed according to the reference they used to grade their tumors (e.g., Edmondson–Steiner, World Health Organization).ResultsWe reviewed a total of 216 articles: 114 enclosed adequate information and were included herein. Among these, we found divergences and inaccuracies in the histological grade assessment of this cancer, which might have led to a non-standardized grade distribution, with further impact on data analysis. Nevertheless, in most of them, poor tumor differentiation correlated with worse prognosis, expressed by lower overall and/or disease-free survival.ConclusionWhile histological grading of HCC has an important prognostic role, there is an unsatisfactory heterogeneity on the microscopic assessment of this tumor, urging for a movement toward standardization. |
topic |
hepatocellular carcinoma histological grading grading systems Edmondson and Steiner prognosis |
url |
http://journal.frontiersin.org/article/10.3389/fmed.2017.00193/full |
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