Effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery

• Main Author: Jun-Yang He
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-02-01
• Series: Journal of Hainan Medical University
• Subjects: Non-small cell lung cancer; Radical operation for lung cancer; Dexmedetomidine; Immune function; Inflammatory stress response
• Online Access: http://www.hnykdxxb.com/PDF/201802/29.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery. Methods: Patients with non-small cell lung cancer who underwent radical operation for lung cancer in Xi'an Aerospace General Hospital between August 2014 and September 2017 were selected and randomly divided into the Dex group who received dexmedetomidine pretreatment combined with general anesthesia and the control group who received routine general anesthesia. The same day after surgery and 3 d after surgery, the peripheral blood was collected respectively to determine the contents of immune cells and the serum was collected respectively to determine the contents of inflammatory stress response indexes. Results: The same day after surgery and 3 d after surgery, CD3+CD4+T cell, CD3+CD8+T cell and CD16+CD56+NK cell contents in peripheral blood of Dex group were significantly higher than those of control group whereas CD11b+CD15+CD33+CD14-G-MDSC, CD11b+CD15- CD33+CD14+M-MDSC and CD4+CD25+CD127lowTreg contents in peripheral blood as well as TNF-α, SAA, CRP, IL-8, IL-10, Cor, Ins, NE, E and AT-II contents in serum were significantly lower than those of control group. Conclusion: Dexmedetomidine pretreatment can improve the immune function and inhibit the inflammatory stress response in patients with non-small cell lung cancer surgery.