TLR7 influences germinal center selection in murine SLE.
TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain trans...
Main Authors: | Alexis Boneparth, Weiqing Huang, Ramalingam Bethunaickan, Megan Woods, Ranjit Sahu, Shitij Arora, Meredith Akerman, Martin Lesser, Anne Davidson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4368537?pdf=render |
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