Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

We used a sensitization approach that involves replacement of the gatekeeper residue in a protein kinase with one with a different side chain. The activity of the enzyme with a bulky gatekeeper residue, such as methionine, cannot be inhibited using bumped kinase inhibitors (BKIs). Here, we have used...

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Bibliographic Details
Main Authors: Abhisheka Bansal, Kayode K. Ojo, Jianbing Mu, Dustin J. Maly, Wesley C. Van Voorhis, Louis H. Miller
Format: Article
Language:English
Published: American Society for Microbiology 2016-12-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/6/e02011-16

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