Spinal cord neural stem cells heterogeneity in postnatal development
Neural stem cells are capable of generating new neurons during development as well as in the adulthood and represent one of the most promising tools to replace lost or damaged neurons after injury or neurodegenerative disease. Unlike the brain, neurogenesis in the adult spinal cord is poorly explor...
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doaj-221ed79114514dcc947b8f0fde2081332020-11-25T03:41:06ZengInnovation Publishing House Pte. Ltd.STEMedicine2705-11882020-01-011110.37175/stemedicine.v1i1.19Spinal cord neural stem cells heterogeneity in postnatal developmentJelena Ban0Miranda Mladinic1Laboratory for Molecular Neurobiology, Department of Biotechnology, University of Rijeka, CroatiaLaboratory for Molecular Neurobiology, Department of Biotechnology, University of Rijeka, Croatia Neural stem cells are capable of generating new neurons during development as well as in the adulthood and represent one of the most promising tools to replace lost or damaged neurons after injury or neurodegenerative disease. Unlike the brain, neurogenesis in the adult spinal cord is poorly explored and the comprehensive characterization of the cells that constitute stem cell neurogenic niche is still missing. Moreover, the terminology used to specify developmental and/or anatomical CNS regions, where neurogenesis in the spinal cord occurs, is not consensual and the analogy with the brain is often unclear. In this review, we will try to describe the heterogeneity of the stem cell types in the spinal cord ependymal zone, based on their origin and stem cell potential. We will also consider specific animal in vitro models that could be useful to identify “the right” stem cell candidate for cell replacement therapies. https://stemedicine.org/index.php/stem/article/view/19Neural stem cellsRadial gliaEpendymal cellsDevelopmentSpinal cord injury |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jelena Ban Miranda Mladinic |
spellingShingle |
Jelena Ban Miranda Mladinic Spinal cord neural stem cells heterogeneity in postnatal development STEMedicine Neural stem cells Radial glia Ependymal cells Development Spinal cord injury |
author_facet |
Jelena Ban Miranda Mladinic |
author_sort |
Jelena Ban |
title |
Spinal cord neural stem cells heterogeneity in postnatal development |
title_short |
Spinal cord neural stem cells heterogeneity in postnatal development |
title_full |
Spinal cord neural stem cells heterogeneity in postnatal development |
title_fullStr |
Spinal cord neural stem cells heterogeneity in postnatal development |
title_full_unstemmed |
Spinal cord neural stem cells heterogeneity in postnatal development |
title_sort |
spinal cord neural stem cells heterogeneity in postnatal development |
publisher |
Innovation Publishing House Pte. Ltd. |
series |
STEMedicine |
issn |
2705-1188 |
publishDate |
2020-01-01 |
description |
Neural stem cells are capable of generating new neurons during development as well as in the adulthood and represent one of the most promising tools to replace lost or damaged neurons after injury or neurodegenerative disease. Unlike the brain, neurogenesis in the adult spinal cord is poorly explored and the comprehensive characterization of the cells that constitute stem cell neurogenic niche is still missing. Moreover, the terminology used to specify developmental and/or anatomical CNS regions, where neurogenesis in the spinal cord occurs, is not consensual and the analogy with the brain is often unclear. In this review, we will try to describe the heterogeneity of the stem cell types in the spinal cord ependymal zone, based on their origin and stem cell potential. We will also consider specific animal in vitro models that could be useful to identify “the right” stem cell candidate for cell replacement therapies.
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topic |
Neural stem cells Radial glia Ependymal cells Development Spinal cord injury |
url |
https://stemedicine.org/index.php/stem/article/view/19 |
work_keys_str_mv |
AT jelenaban spinalcordneuralstemcellsheterogeneityinpostnataldevelopment AT mirandamladinic spinalcordneuralstemcellsheterogeneityinpostnataldevelopment |
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1724531684515250176 |