Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial
Abstract Background Globally, it is known that HIV-infected pregnant women are prone to depressive symptoms. Research evidences also suggest that nutrient deficiencies may enhance the depressive illness, and that fish oil omega-3 fatty acids may alleviate the depressive symptoms. The aim of this stu...
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doaj-222905111b3f4e8a8633c7ce0fd917612020-11-25T00:39:59ZengBMCAnnals of General Psychiatry1744-859X2018-11-0117111610.1186/s12991-018-0220-4Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trialRose Okoyo Opiyo0Peter Suwirakwenda Nyasulu1Reuben Kamau Koigi2Anne Obondo3Dorington OgoyiWambui Kogi-Makau4School of Public Health, University of NairobiDivision of Epidemiology & Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch UniversityDepartment of Obstetrics and Gynecology, University of NairobiDepartment of Psychiatry, University of NairobiDepartment of Food Science, Nutrition and Technology, University of NairobiAbstract Background Globally, it is known that HIV-infected pregnant women are prone to depressive symptoms. Research evidences also suggest that nutrient deficiencies may enhance the depressive illness, and that fish oil omega-3 fatty acids may alleviate the depressive symptoms. The aim of this study was to assess the effect of fish oil omega-3 eicosapentaenoic acid-rich supplements on depressive symptoms among HIV-seropositive pregnant women. Trial design A randomized double-blinded controlled trial with two parallel groups was conducted. The intervention group received fish oil omega-3 of 3.17 g (eicosapentaenoic acid = 2.15 g; docosahexaenoic acid = 1.02 g) per day for 8 weeks, while the control group received soybean oil for a similar period. Method Participants were HIV-seropositive pregnant women who were enrolled in prevention of mother-to-child transmission programs and attending antenatal clinics at selected Nairobi city county’s health facilities. Recruitment was done from health records of HIV-infected pregnant women. Data analysis followed per-protocol analysis. Participants who completed the 8-week trial were included in the analysis of covariance statistical model with omega-3 as main effect. The covariates in the change in BDI-II depressive symptom score outcome were baseline characteristics and nutrient adequacy. Results 282 participants were recruited 109 randomized to fish oil, and 107 to soybean oil. Completion rate was 86/109 (78.9%) and 96/107 (89.7%) respectively. At the end of week-8 of follow up most participants in both arms had mild depressive symptoms 82/86 (95.3%) in the Fish oil group and 94/96 (97.9%) in the Soybean oil group. The difference in effect between the intervention and control group was not statistically significant (1.01 (95% CI − 0.58 to 2.60), p = 0.21). Conclusion Fish oil omega-3 with a daily dosage of 3.17 g (eicosapentaenoic acid = 2.15 g; docosahexaenoic acid = 1.02 g) appears to provide no added benefit in reduction of the symptoms of depression in HIV-infected pregnant women. Trial Registration Clinical Trial Registry: NCT01614249. Registered on June 5, 2012. https://clinicaltrials.gov/ct2/show/NCT01614249http://link.springer.com/article/10.1186/s12991-018-0220-4Omega-3Fish oilDepressionHIV infectionPregnancyRCT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rose Okoyo Opiyo Peter Suwirakwenda Nyasulu Reuben Kamau Koigi Anne Obondo Dorington Ogoyi Wambui Kogi-Makau |
spellingShingle |
Rose Okoyo Opiyo Peter Suwirakwenda Nyasulu Reuben Kamau Koigi Anne Obondo Dorington Ogoyi Wambui Kogi-Makau Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial Annals of General Psychiatry Omega-3 Fish oil Depression HIV infection Pregnancy RCT |
author_facet |
Rose Okoyo Opiyo Peter Suwirakwenda Nyasulu Reuben Kamau Koigi Anne Obondo Dorington Ogoyi Wambui Kogi-Makau |
author_sort |
Rose Okoyo Opiyo |
title |
Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial |
title_short |
Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial |
title_full |
Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial |
title_fullStr |
Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial |
title_full_unstemmed |
Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial |
title_sort |
effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among hiv-seropositive pregnant women: a randomized, double-blind controlled trial |
publisher |
BMC |
series |
Annals of General Psychiatry |
issn |
1744-859X |
publishDate |
2018-11-01 |
description |
Abstract Background Globally, it is known that HIV-infected pregnant women are prone to depressive symptoms. Research evidences also suggest that nutrient deficiencies may enhance the depressive illness, and that fish oil omega-3 fatty acids may alleviate the depressive symptoms. The aim of this study was to assess the effect of fish oil omega-3 eicosapentaenoic acid-rich supplements on depressive symptoms among HIV-seropositive pregnant women. Trial design A randomized double-blinded controlled trial with two parallel groups was conducted. The intervention group received fish oil omega-3 of 3.17 g (eicosapentaenoic acid = 2.15 g; docosahexaenoic acid = 1.02 g) per day for 8 weeks, while the control group received soybean oil for a similar period. Method Participants were HIV-seropositive pregnant women who were enrolled in prevention of mother-to-child transmission programs and attending antenatal clinics at selected Nairobi city county’s health facilities. Recruitment was done from health records of HIV-infected pregnant women. Data analysis followed per-protocol analysis. Participants who completed the 8-week trial were included in the analysis of covariance statistical model with omega-3 as main effect. The covariates in the change in BDI-II depressive symptom score outcome were baseline characteristics and nutrient adequacy. Results 282 participants were recruited 109 randomized to fish oil, and 107 to soybean oil. Completion rate was 86/109 (78.9%) and 96/107 (89.7%) respectively. At the end of week-8 of follow up most participants in both arms had mild depressive symptoms 82/86 (95.3%) in the Fish oil group and 94/96 (97.9%) in the Soybean oil group. The difference in effect between the intervention and control group was not statistically significant (1.01 (95% CI − 0.58 to 2.60), p = 0.21). Conclusion Fish oil omega-3 with a daily dosage of 3.17 g (eicosapentaenoic acid = 2.15 g; docosahexaenoic acid = 1.02 g) appears to provide no added benefit in reduction of the symptoms of depression in HIV-infected pregnant women. Trial Registration Clinical Trial Registry: NCT01614249. Registered on June 5, 2012. https://clinicaltrials.gov/ct2/show/NCT01614249 |
topic |
Omega-3 Fish oil Depression HIV infection Pregnancy RCT |
url |
http://link.springer.com/article/10.1186/s12991-018-0220-4 |
work_keys_str_mv |
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