Potential biomarkers for bipolar disorder: Where do we stand?
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the...
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doaj-222d34b081374451b6c800c1ed211be42020-11-24T21:03:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Research0971-59162017-01-01145171610.4103/ijmr.IJMR_1386_16Potential biomarkers for bipolar disorder: Where do we stand?Rajesh SagarRaman Deep PattanayakBipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes. Due to the heterogeneity of BD, the possibility of developing a single, specific biomarker is still remote; however, there is a set of promising biomarkers which may serve as predictive, prognostic or treatment markers in the future. The review presents a critical appraisal and update on some of the most promising candidates for biomarkers, namely, neuroimaging markers, peripheral biomarkers and genetic markers, including a brief discussion on cognitive endophenotypes as indicative of genetic risk. The lessons learnt from other fields and specialties in medicine need to be applied to psychiatry to translate the knowledge from 'bench to bedside' by means of clinically useful biomarkers. Overall, the biomarkers may help in pushing the shift towards personalized medicine for psychiatric patients.http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=145;issue=1;spage=7;epage=16;aulast=SagarBiomarkers - BDNF- bipolar disorder - cognitive endophenotypes - neuroimaging biomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rajesh Sagar Raman Deep Pattanayak |
spellingShingle |
Rajesh Sagar Raman Deep Pattanayak Potential biomarkers for bipolar disorder: Where do we stand? Indian Journal of Medical Research Biomarkers - BDNF- bipolar disorder - cognitive endophenotypes - neuroimaging biomarkers |
author_facet |
Rajesh Sagar Raman Deep Pattanayak |
author_sort |
Rajesh Sagar |
title |
Potential biomarkers for bipolar disorder: Where do we stand? |
title_short |
Potential biomarkers for bipolar disorder: Where do we stand? |
title_full |
Potential biomarkers for bipolar disorder: Where do we stand? |
title_fullStr |
Potential biomarkers for bipolar disorder: Where do we stand? |
title_full_unstemmed |
Potential biomarkers for bipolar disorder: Where do we stand? |
title_sort |
potential biomarkers for bipolar disorder: where do we stand? |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Medical Research |
issn |
0971-5916 |
publishDate |
2017-01-01 |
description |
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes. Due to the heterogeneity of BD, the possibility of developing a single, specific biomarker is still remote; however, there is a set of promising biomarkers which may serve as predictive, prognostic or treatment markers in the future. The review presents a critical appraisal and update on some of the most promising candidates for biomarkers, namely, neuroimaging markers, peripheral biomarkers and genetic markers, including a brief discussion on cognitive endophenotypes as indicative of genetic risk. The lessons learnt from other fields and specialties in medicine need to be applied to psychiatry to translate the knowledge from 'bench to bedside' by means of clinically useful biomarkers. Overall, the biomarkers may help in pushing the shift towards personalized medicine for psychiatric patients. |
topic |
Biomarkers - BDNF- bipolar disorder - cognitive endophenotypes - neuroimaging biomarkers |
url |
http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=145;issue=1;spage=7;epage=16;aulast=Sagar |
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