An analytical study of etiopathological factors responsible for oral squamous cell carcinoma in Bihar population

• Main Authors: Tanoj Kumar, Sanjay Manohar Kanade, Rohit Singh, Alisha Singh, Avanindra Kumar, Vardar R Hiremath
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Journal of Pharmacy and Bioallied Sciences
• Subjects: cancer of maxillofacial region; histopathology; neoplasia; oral squamous cell carcinoma; oropharyngeal cancer
• Online Access: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=222;epage=227;aulast=Kumar

Background: Squamous cell carcinoma (SCC) of maxillofacial region is the most usual form of neoplasia causing malignancies in India and Asian continent. An increased prevalence of mortality rate by cancer of maxillofacial region was observed in various parts of the world. Objectives: Our aim was to correlate age and gender with etiopathological factors contributing to oral squamous cell carcinoma (OSCC) in the urban population of Patna in 2 years. Materials and Methods: Data were extracted from hospital records. A total of 236 cases of histologically confirmed mild to advance stage of OSCC in either gender of 15–80 years of age range were evaluated. Results: Out of 236 histopathologically confirmed patients with OSCC, 172 were male and 64 were female. Insignificant difference was found in all age-groups and in all locations. Most common site was found to be buccal mucosa in both genders. Bony invasion was found to be least common. In our study, it was found that habits of chewing areca nuts, nicotine smoke addiction, consumption of alcohol, combination of chewing nuts and nicotine smoke addiction, and combination of alcohol and nicotine smoke addiction are significantly related to the development of OSCC. No significant association was found between histopathological conclusion and gender in all the four groups, and the prevalence was directly proportional to advancement of age. Conclusion: We concluded that the OSCC do not have any significant relation with the age and gender. The habit of nicotine and areca nut chewing, nicotine smoke addiction, and combination of nicotine smoke addiction and alcohol and chewing nut and nicotine smoke addiction has significant relationship in the development of OSCC.