Staphylococcal phages and pathogenicity islands drive plasmid evolution

Staphylococcal phages and pathogenicity islands drive plasmid evolution

Many plasmids can be transferred between bacterial cells via conjugation; however, the mechanisms underlying the transfer of non-conjugative plasmids are less clear. Here, Humphrey et al. show that staphylococcal phages and a family of pathogenicity islands (PICIs) can mediate intra- and inter-speci...

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Main Authors: Suzanne Humphrey, Álvaro San Millán, Macarena Toll-Riera, John Connolly, Alejandra Flor-Duro, John Chen, Carles Ubeda, R. Craig MacLean, José R. Penadés
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26101-5
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spelling doaj-223838baccfd4b7e90e35bc7462be7672021-10-10T11:44:36ZengNature Publishing GroupNature Communications2041-17232021-10-0112111510.1038/s41467-021-26101-5Staphylococcal phages and pathogenicity islands drive plasmid evolutionSuzanne Humphrey0Álvaro San Millán1Macarena Toll-Riera2John Connolly3Alejandra Flor-Duro4John Chen5Carles Ubeda6R. Craig MacLean7José R. Penadés8Institute of Infection, Immunity and Inflammation, University of GlasgowCentro Nacional de Biotecnología–CSICInstitute of Integrative Biology, ETH ZurichInstitute of Infection, Immunity and Inflammation, University of GlasgowFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-FISABIODepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of SingaporeFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-FISABIODepartment of Zoology, University of OxfordInstitute of Infection, Immunity and Inflammation, University of GlasgowMany plasmids can be transferred between bacterial cells via conjugation; however, the mechanisms underlying the transfer of non-conjugative plasmids are less clear. Here, Humphrey et al. show that staphylococcal phages and a family of pathogenicity islands (PICIs) can mediate intra- and inter-species plasmid transfer via generalised transduction.https://doi.org/10.1038/s41467-021-26101-5
collection DOAJ
language English
format Article
sources DOAJ
author Suzanne Humphrey
Álvaro San Millán
Macarena Toll-Riera
John Connolly
Alejandra Flor-Duro
John Chen
Carles Ubeda
R. Craig MacLean
José R. Penadés
spellingShingle Suzanne Humphrey
Álvaro San Millán
Macarena Toll-Riera
John Connolly
Alejandra Flor-Duro
John Chen
Carles Ubeda
R. Craig MacLean
José R. Penadés
Staphylococcal phages and pathogenicity islands drive plasmid evolution
Nature Communications
author_facet Suzanne Humphrey
Álvaro San Millán
Macarena Toll-Riera
John Connolly
Alejandra Flor-Duro
John Chen
Carles Ubeda
R. Craig MacLean
José R. Penadés
author_sort Suzanne Humphrey
title Staphylococcal phages and pathogenicity islands drive plasmid evolution
title_short Staphylococcal phages and pathogenicity islands drive plasmid evolution
title_full Staphylococcal phages and pathogenicity islands drive plasmid evolution
title_fullStr Staphylococcal phages and pathogenicity islands drive plasmid evolution
title_full_unstemmed Staphylococcal phages and pathogenicity islands drive plasmid evolution
title_sort staphylococcal phages and pathogenicity islands drive plasmid evolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-10-01
description Many plasmids can be transferred between bacterial cells via conjugation; however, the mechanisms underlying the transfer of non-conjugative plasmids are less clear. Here, Humphrey et al. show that staphylococcal phages and a family of pathogenicity islands (PICIs) can mediate intra- and inter-species plasmid transfer via generalised transduction.
url https://doi.org/10.1038/s41467-021-26101-5
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