Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea
Background Obstructive sleep apnea syndrome (OSAS) is associated with the respiratory tract inflammation. Fractional exhaled nitric oxide (FeNO) and high-sensitivity C-reactive protein (Hs-CRP) are indicators of airway and systemic inflammation. Few revisions have explored the effect of continuous p...
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doaj-2252749c8b7c431bb4f39638c73e8ee12021-06-15T04:29:18ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502021-01-0170227227510.4103/ejcdt.ejcdt_85_20Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apneaMona El WassefyMariam SabryMohsen RlshafeyAhmed M HamadLucy Abdelmaboud SulimanBackground Obstructive sleep apnea syndrome (OSAS) is associated with the respiratory tract inflammation. Fractional exhaled nitric oxide (FeNO) and high-sensitivity C-reactive protein (Hs-CRP) are indicators of airway and systemic inflammation. Few revisions have explored the effect of continuous positive airway pressure (CPAP) on both indicators in OSAS. Purpose To study the influence of CPAP therapy on exhaled NO and Hs-CRP in OSAS. Patients and methods This is a case–control study that included 27 participants with OSAS and 10 controls enlisted from a sleep outpatient clinic. Full-night polysomnography was performed, and the next morning, FeNO and Hs-CRP were evaluated. CPAP for patients with moderate to severe OSA was advised with measurement of FeNO and Hs-CRP after 3 months of CPAP. Results Both FeNO and Hs-CRP in patients with OSA were statistically significantly increased against the control group. However, after 3 months of CPAP therapy, there was a statistically significant decrease in both FeNO and Hs-CRP. Conclusion Upper airway and systemic inflammation are extant in OSAS, reinforced by increases in both FeNO and CRP, and CPAP therapy diminishes FeNO levels in patients with OSA.http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=2;spage=272;epage=275;aulast=continuous positive airway pressurefractional exhaled nitric oxidehigh-sensitivity c-reactive proteinobstructive sleep apnea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mona El Wassefy Mariam Sabry Mohsen Rlshafey Ahmed M Hamad Lucy Abdelmaboud Suliman |
spellingShingle |
Mona El Wassefy Mariam Sabry Mohsen Rlshafey Ahmed M Hamad Lucy Abdelmaboud Suliman Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea Egyptian Journal of Chest Disease and Tuberculosis continuous positive airway pressure fractional exhaled nitric oxide high-sensitivity c-reactive protein obstructive sleep apnea |
author_facet |
Mona El Wassefy Mariam Sabry Mohsen Rlshafey Ahmed M Hamad Lucy Abdelmaboud Suliman |
author_sort |
Mona El Wassefy |
title |
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea |
title_short |
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea |
title_full |
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea |
title_fullStr |
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea |
title_full_unstemmed |
Effect of continuous positive airway pressure therapy on exhaled nitric oxide and C-reactive protein as markers of inflammation in Egyptian patients with obstructive sleep apnea |
title_sort |
effect of continuous positive airway pressure therapy on exhaled nitric oxide and c-reactive protein as markers of inflammation in egyptian patients with obstructive sleep apnea |
publisher |
Wolters Kluwer Medknow Publications |
series |
Egyptian Journal of Chest Disease and Tuberculosis |
issn |
0422-7638 2090-9950 |
publishDate |
2021-01-01 |
description |
Background Obstructive sleep apnea syndrome (OSAS) is associated with the respiratory tract inflammation. Fractional exhaled nitric oxide (FeNO) and high-sensitivity C-reactive protein (Hs-CRP) are indicators of airway and systemic inflammation. Few revisions have explored the effect of continuous positive airway pressure (CPAP) on both indicators in OSAS.
Purpose To study the influence of CPAP therapy on exhaled NO and Hs-CRP in OSAS.
Patients and methods This is a case–control study that included 27 participants with OSAS and 10 controls enlisted from a sleep outpatient clinic. Full-night polysomnography was performed, and the next morning, FeNO and Hs-CRP were evaluated. CPAP for patients with moderate to severe OSA was advised with measurement of FeNO and Hs-CRP after 3 months of CPAP.
Results Both FeNO and Hs-CRP in patients with OSA were statistically significantly increased against the control group. However, after 3 months of CPAP therapy, there was a statistically significant decrease in both FeNO and Hs-CRP.
Conclusion Upper airway and systemic inflammation are extant in OSAS, reinforced by increases in both FeNO and CRP, and CPAP therapy diminishes FeNO levels in patients with OSA. |
topic |
continuous positive airway pressure fractional exhaled nitric oxide high-sensitivity c-reactive protein obstructive sleep apnea |
url |
http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=2;spage=272;epage=275;aulast= |
work_keys_str_mv |
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