Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
Background Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreated...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2020-08-01
|
Series: | RMD Open |
Online Access: | https://rmdopen.bmj.com/content/6/2/e001278.full |
id |
doaj-225b5dfcdff745688344e2821cc9513a |
---|---|
record_format |
Article |
spelling |
doaj-225b5dfcdff745688344e2821cc9513a2020-12-14T15:28:11ZengBMJ Publishing GroupRMD Open2056-59332020-08-016210.1136/rmdopen-2020-001278Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritisKaterina Chatzidionysiou0Magnus Sköld1Monica Hansson2Guy Serre3Vijay Joshua4Aase Haj Hensvold5Gudrun Reynisdottir6Martin Cornillet7Leonor Nogueira8Sven Nyren9Reza Karimi10Anders Eklund11Johan Grunewald12Anca Catrina13st Department of Propaedeutic and Internal Medicine, Joint Rheumatology Program, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Attica, Greece4 Division of Respiratory Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden 1 Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden2 Unité Différenciation Épithéliale et Autoimmunité Rhumatoïde, Unité Mixte de Recherche 1056, INSERM – Université de Toulouse, Toulouse, FranceRheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenRheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden1 Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden2 Unité Différenciation Épithéliale et Autoimmunité Rhumatoïde, Unité Mixte de Recherche 1056, INSERM – Université de Toulouse, Toulouse, France2 Unité Différenciation Épithéliale et Autoimmunité Rhumatoïde, Unité Mixte de Recherche 1056, INSERM – Université de Toulouse, Toulouse, France3 Department of Radiology, Karolinska University Hospital, Stockholm, Sweden4 Division of Respiratory Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden4 Division of Respiratory Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden4 Division of Respiratory Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden1 Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, SwedenBackground Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreated RA.Methods 106 patients with newly diagnosed untreated RA were examined with HRCT of the lungs. Blood samples were analysed for presence of rheumatoid factor (RF) and ACPA using either a CCP2 detection kit or an immunochip containing 10 different citrullinated peptides. Association between HRCT findings and the antibody repertoire was assessed by logistic regression analysis.Results The number (%) of patients with HRCT abnormalities was 58 (54.7%) for parenchymal abnormalities and 68 (64.2%) for airway abnormalities. CCP2 IgG, RF IgA and antibodies against citrullinated fibrinogen were associated with the presence of parenchymal lung abnormalities. Interestingly, a high number of ACPA fine specificities gave a high risk of having parenchymal lung abnormalities at the time of RA diagnosis. No significant signals were identified between ACPA specificities and risk for airway abnormalities.Conclusions The presence of RF and ACPAs (especially against citrullinated fibrinogen peptides) as well as high number of ACPAs fine specificities are associated with parenchymal lung abnormalities in patients with early, untreated RA. This provides further support for an important pathogenic link between the lung and systemic autoimmunity, contributing to RA development.https://rmdopen.bmj.com/content/6/2/e001278.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katerina Chatzidionysiou Magnus Sköld Monica Hansson Guy Serre Vijay Joshua Aase Haj Hensvold Gudrun Reynisdottir Martin Cornillet Leonor Nogueira Sven Nyren Reza Karimi Anders Eklund Johan Grunewald Anca Catrina |
spellingShingle |
Katerina Chatzidionysiou Magnus Sköld Monica Hansson Guy Serre Vijay Joshua Aase Haj Hensvold Gudrun Reynisdottir Martin Cornillet Leonor Nogueira Sven Nyren Reza Karimi Anders Eklund Johan Grunewald Anca Catrina Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis RMD Open |
author_facet |
Katerina Chatzidionysiou Magnus Sköld Monica Hansson Guy Serre Vijay Joshua Aase Haj Hensvold Gudrun Reynisdottir Martin Cornillet Leonor Nogueira Sven Nyren Reza Karimi Anders Eklund Johan Grunewald Anca Catrina |
author_sort |
Katerina Chatzidionysiou |
title |
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
title_short |
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
title_full |
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
title_fullStr |
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
title_full_unstemmed |
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
title_sort |
association between number and type of different acpa fine specificities with lung abnormalities in early, untreated rheumatoid arthritis |
publisher |
BMJ Publishing Group |
series |
RMD Open |
issn |
2056-5933 |
publishDate |
2020-08-01 |
description |
Background Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreated RA.Methods 106 patients with newly diagnosed untreated RA were examined with HRCT of the lungs. Blood samples were analysed for presence of rheumatoid factor (RF) and ACPA using either a CCP2 detection kit or an immunochip containing 10 different citrullinated peptides. Association between HRCT findings and the antibody repertoire was assessed by logistic regression analysis.Results The number (%) of patients with HRCT abnormalities was 58 (54.7%) for parenchymal abnormalities and 68 (64.2%) for airway abnormalities. CCP2 IgG, RF IgA and antibodies against citrullinated fibrinogen were associated with the presence of parenchymal lung abnormalities. Interestingly, a high number of ACPA fine specificities gave a high risk of having parenchymal lung abnormalities at the time of RA diagnosis. No significant signals were identified between ACPA specificities and risk for airway abnormalities.Conclusions The presence of RF and ACPAs (especially against citrullinated fibrinogen peptides) as well as high number of ACPAs fine specificities are associated with parenchymal lung abnormalities in patients with early, untreated RA. This provides further support for an important pathogenic link between the lung and systemic autoimmunity, contributing to RA development. |
url |
https://rmdopen.bmj.com/content/6/2/e001278.full |
work_keys_str_mv |
AT katerinachatzidionysiou associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT magnusskold associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT monicahansson associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT guyserre associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT vijayjoshua associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT aasehajhensvold associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT gudrunreynisdottir associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT martincornillet associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT leonornogueira associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT svennyren associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT rezakarimi associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT anderseklund associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT johangrunewald associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis AT ancacatrina associationbetweennumberandtypeofdifferentacpafinespecificitieswithlungabnormalitiesinearlyuntreatedrheumatoidarthritis |
_version_ |
1724383439755411456 |