IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR
Aim. The purpose of our work was to estimate the impact of preconditioning with acetylcysteine and sevoflurane on ischemia-reperfusion injury of cadaveric donor liver with marginal features. Methods and results. In this prospective randomized controlled trial we recruited 21 heart beating donors wit...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
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Online Access: | https://journal.transpl.ru/vtio/article/view/138 |
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doaj-225c318ea3464fdfbaf8685b6fd2c6c02021-07-29T09:08:26ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov Vestnik Transplantologii i Iskusstvennyh Organov1995-11912013-03-01151394410.15825/1995-1191-2013-1-39-4481IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONORA. E. Shcherba0S. V. Korotkov1A. F. Minov2Y. V. Slobodin3M. M. Savchuk4A. M. Dzyadzko5O. O. Rummo6Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of BelarusRepublican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9Aim. The purpose of our work was to estimate the impact of preconditioning with acetylcysteine and sevoflurane on ischemia-reperfusion injury of cadaveric donor liver with marginal features. Methods and results. In this prospective randomized controlled trial we recruited 21 heart beating donors with brain death. We assigned 11 donors to the study group, and 10 donors to the control group. Morphological characteristics of ischemia- reperfusion injury in both groups were analyzed. Conclusion. Use of pharmacological preconditioning with acetylcysteine and sevoflurane resulted in necrosis and hepatocyte apoptosis reduction as compared to the control group, thereby had a protective effect against ischemia-reperfusion injury.https://journal.transpl.ru/vtio/article/view/138sevofluraneacetylcysteineischemia-reperfusion injurymarginal liver graft |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. E. Shcherba S. V. Korotkov A. F. Minov Y. V. Slobodin M. M. Savchuk A. M. Dzyadzko O. O. Rummo |
spellingShingle |
A. E. Shcherba S. V. Korotkov A. F. Minov Y. V. Slobodin M. M. Savchuk A. M. Dzyadzko O. O. Rummo IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR Vestnik Transplantologii i Iskusstvennyh Organov sevoflurane acetylcysteine ischemia-reperfusion injury marginal liver graft |
author_facet |
A. E. Shcherba S. V. Korotkov A. F. Minov Y. V. Slobodin M. M. Savchuk A. M. Dzyadzko O. O. Rummo |
author_sort |
A. E. Shcherba |
title |
IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR |
title_short |
IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR |
title_full |
IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR |
title_fullStr |
IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR |
title_full_unstemmed |
IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR |
title_sort |
impact of sevoflurane and acetylcysteine on ischemia-reperfusion injury of the liver from brain-dead donor |
publisher |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
series |
Vestnik Transplantologii i Iskusstvennyh Organov |
issn |
1995-1191 |
publishDate |
2013-03-01 |
description |
Aim. The purpose of our work was to estimate the impact of preconditioning with acetylcysteine and sevoflurane on ischemia-reperfusion injury of cadaveric donor liver with marginal features. Methods and results. In this prospective randomized controlled trial we recruited 21 heart beating donors with brain death. We assigned 11 donors to the study group, and 10 donors to the control group. Morphological characteristics of ischemia- reperfusion injury in both groups were analyzed. Conclusion. Use of pharmacological preconditioning with acetylcysteine and sevoflurane resulted in necrosis and hepatocyte apoptosis reduction as compared to the control group, thereby had a protective effect against ischemia-reperfusion injury. |
topic |
sevoflurane acetylcysteine ischemia-reperfusion injury marginal liver graft |
url |
https://journal.transpl.ru/vtio/article/view/138 |
work_keys_str_mv |
AT aeshcherba impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT svkorotkov impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT afminov impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT yvslobodin impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT mmsavchuk impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT amdzyadzko impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor AT oorummo impactofsevofluraneandacetylcysteineonischemiareperfusioninjuryoftheliverfrombraindeaddonor |
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