Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised ce...

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Main Authors:	Xiaoming Sun, Stephane Hua, Ce Gao, Jane E. Blackmer, Zhengyu Ouyang, Kevin Ard, Andrea Ciaranello, Sigal Yawetz, Paul E. Sax, Eric S. Rosenberg, Mathias Lichterfeld, Xu G. Yu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16217-5

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spelling	doaj-22635906b94d4ef385dfa69cc1d812bc2021-05-16T11:12:03ZengNature Publishing GroupNature Communications2041-17232020-05-0111111310.1038/s41467-020-16217-5Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulationXiaoming Sun0Stephane Hua1Ce Gao2Jane E. Blackmer3Zhengyu Ouyang4Kevin Ard5Andrea Ciaranello6Sigal Yawetz7Paul E. Sax8Eric S. Rosenberg9Mathias Lichterfeld10Xu G. Yu11Ragon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalInfectious Disease Division, Massachusetts General HospitalInfectious Disease Division, Massachusetts General HospitalInfectious Disease Division, Brigham and Women’s HospitalInfectious Disease Division, Brigham and Women’s HospitalInfectious Disease Division, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalRagon Institute of MGH, MIT, and Harvard, Massachusetts General HospitalZika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.https://doi.org/10.1038/s41467-020-16217-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu
spellingShingle	Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation Nature Communications
author_facet	Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu
author_sort	Xiaoming Sun
title	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_short	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_full	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_fullStr	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_full_unstemmed	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_sort	immune-profiling of zikv-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.
url	https://doi.org/10.1038/s41467-020-16217-5
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Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

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