THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN
Chromium (VI) is a widely used industrial chemical, extensively used in paints, metal finishes, steel including stainless steel manufacturing, alloy cast irons, chrome, and wood treatment. In nature chromium occurs in divalent, trivalent and hexavalent forms. Hexavalent chromium predominates over th...
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doaj-226ea6340fee4db5a0df7b9d06b543f02020-11-25T03:41:13ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762009-05-01421368372921THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEANCORINA GRĂVILĂ0LETIŢIA STANA1SNEJANA PETROVICI2ALEXANDRA TRIF3Faculty of Animal Sciences and Biotechnologies, TimişoaraFaculty of Veterinary Medicine, TimişoaraFaculty of Veterinary Medicine, TimişoaraFaculty of Veterinary Medicine, TimişoaraChromium (VI) is a widely used industrial chemical, extensively used in paints, metal finishes, steel including stainless steel manufacturing, alloy cast irons, chrome, and wood treatment. In nature chromium occurs in divalent, trivalent and hexavalent forms. Hexavalent chromium predominates over the trivalent form in natural waters. We have studied the influence of potassium dichromate (K2Cr2O7) on blood GSH values in rats. This study was carried out on 28 Wistar adult female rats, divided in 3 experimental groups (E) and one control group (C). The rats were feed with 25ppm (LOAEL), 50ppm and 75ppm potassium dichromate, ad libitum, in drinking water, during the gestation. The control batch received tap water. Reduced glutathione (GSH) was measured quantitatively after the wean using a Perkin-Elmer spectrophotometer, through Beutler et al. method, at 412nm. This study reports that potassium dichromate exposure induced the depletion of blood GSH because Cr(VI) can generate reactive oxygen species (ROS). It can induce oxidative stress and toxicity.http://spasb.ro/index.php/spasb/article/view/999gshpotassium dichromateoxidative stressfemale rats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
CORINA GRĂVILĂ LETIŢIA STANA SNEJANA PETROVICI ALEXANDRA TRIF |
spellingShingle |
CORINA GRĂVILĂ LETIŢIA STANA SNEJANA PETROVICI ALEXANDRA TRIF THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN Scientific Papers Animal Science and Biotechnologies gsh potassium dichromate oxidative stress female rats |
author_facet |
CORINA GRĂVILĂ LETIŢIA STANA SNEJANA PETROVICI ALEXANDRA TRIF |
author_sort |
CORINA GRĂVILĂ |
title |
THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN |
title_short |
THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN |
title_full |
THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN |
title_fullStr |
THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN |
title_full_unstemmed |
THE CONSEQUENCES ON BLOOD GSH DYNAMICS ON WISTAR FEMALE RATS AT AD LIBITUM CHROMIUM (VI) ADMINISTRATION DURING THE GESTATION AFTER THE WEAN |
title_sort |
consequences on blood gsh dynamics on wistar female rats at ad libitum chromium (vi) administration during the gestation after the wean |
publisher |
Agroprint Timisoara |
series |
Scientific Papers Animal Science and Biotechnologies |
issn |
1841-9364 2344-4576 |
publishDate |
2009-05-01 |
description |
Chromium (VI) is a widely used industrial chemical, extensively used in paints, metal finishes, steel including stainless steel manufacturing, alloy cast irons, chrome, and wood treatment. In nature chromium occurs in divalent, trivalent and hexavalent forms. Hexavalent chromium predominates over the trivalent form in natural waters. We have studied the influence of potassium dichromate (K2Cr2O7) on blood GSH values in rats. This study was carried out on 28 Wistar adult female rats, divided in 3 experimental groups (E) and one control group (C). The rats were feed with 25ppm (LOAEL), 50ppm and 75ppm potassium dichromate, ad libitum, in drinking water, during the gestation. The control batch received tap water. Reduced glutathione (GSH) was measured quantitatively after the wean using a Perkin-Elmer spectrophotometer, through Beutler et al. method, at 412nm. This study reports that potassium dichromate exposure induced the depletion of blood GSH because Cr(VI) can generate reactive oxygen species (ROS). It can induce oxidative stress and toxicity. |
topic |
gsh potassium dichromate oxidative stress female rats |
url |
http://spasb.ro/index.php/spasb/article/view/999 |
work_keys_str_mv |
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