Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

Parent-of-origin effects comprise a range of genetic and epigenetic mechanisms of inheritance. Recently, detection of such effects implicated epigenetic mechanisms in the etiology of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. We here sought to dissect the...

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Main Authors: Pernilla Stridh, Sabrina Ruhrmann, Petra Bergman, Mélanie Thessén Hedreul, Sevasti Flytzani, Amennai Daniel Beyeen, Alan Gillett, Nina Krivosija, Johan Öckinger, Anne C Ferguson-Smith, Maja Jagodic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3967983?pdf=render

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